段

段文虎 (Wenhu Duan)

Chinese Academy of Sciences

H指数:36

被引数:4,004

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Design; synthesis and pharmacological evaluation of 3H-spiro[benzofuran-2; 4′-piperidine] IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma

设计、合成及药理学评价：用于治疗弥漫性大B细胞淋巴瘤的3H-螺[苯并呋喃-2;4′-哌啶] IRAK4抑制剂

rsc med. chem.

IF0

2026-04-270

PRE

Discovery and optimization of 1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide derivatives as USP1 inhibitors for BRCA1-mutant cancer treatment

1H-吡唑并[3,4-d]嘧啶-3-甲酰胺衍生物作为USP1抑制剂在BRCA1突变癌症治疗中的发现与优化

Bioorganic Chemistry

IF4.7

2026-04-020

PRE

Discovery of isoindoline-2(1H)-carboxamide STING inhibitors as anti-inflammatory agents

作为抗炎剂的异吲哚啉-2(1H)-甲酰胺STING抑制剂的发现

Molecular Diversity

IF3.8

2025-12-110

PRE

Discovery of a potent and orally bioavailable 3,3-dimethyl-2-oxoindoline STING inhibitor

发现一种强效且口服生物利用度高的3,3-二甲基-2-氧代吲哚啉STING抑制剂

European Journal of Medicinal Chemistry

IF5.9

2025-10-090

PRE

Discovery of 3,4-dihydroisoquinoline-2(1H)-carboxamide STING inhibitors as anti-inflammatory agents

作为抗炎药物的3,4-二氢异喹啉-2(1H)-甲酰胺STING抑制剂的发现

European Journal of Medicinal Chemistry

IF5.9

2025-07-010

PRE

Discovery of indole derivatives as STING degraders

作为STING降解剂的吲哚衍生物的发现

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2025-05-280

PRE

Design, synthesis, and biological evaluation of RIPK1-targeting PROTACs

RIPK1-targeting PROTACs的设计、合成及生物学评价

MOLECULAR DIVERSITY

IF3.8

2025-03-010

PRE

Incorporation of a rigid 1,3-diketone-containing fragment led to significantly improved AXL inhibitory activity: design, synthesis, and SAR of the anilinopyrimidine AXL inhibitors

MOLECULAR DIVERSITY

IF3.8

2024-12-280

PRE

Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2024-12-012

PRE

Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas

发现新的BTK抑制剂S-016并确定治疗淋巴瘤 (包括BTK抑制剂耐药淋巴瘤) 的新策略

ACTA PHARMACOLOGICA SINICA

IF8.4

2024-06-040

PRE

Design, synthesis, and evaluation of thiazolecarboxamide derivatives as stimulator of interferon gene inhibitors

噻唑甲酰胺衍生物作为干扰素基因抑制剂刺激剂的设计，合成和评价

MOLECULAR DIVERSITY

IF3.8

2024-04-290

PRE

A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease

新型IRAK4抑制剂DW18134改善腹膜炎和炎症性肠病

MOLECULES

IF4.6

2024-04-162

OAAI

A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy

CANCER COMMUNICATIONS

IF24.9

2024-02-091

OAAI

Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-02-011

PRE

Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole derivatives as necroptosis inhibitors

RSC MEDICINAL CHEMISTRY

IF3.6

2024-01-011

OAAI

Design, synthesis, and STING-agonistic activity of benzo[b]thiophene-2-carboxamide derivatives

MOLECULAR DIVERSITY

IF3.8

2023-10-053

PRE

Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-08-014

PRE

Comparative study of four displacer phase-shifters in a split pulse tube refrigerator working at 170 K

APPLIED THERMAL ENGINEERING

IF6.9

2023-07-015

PRE

Experimental study of ethane pulsating heat pipe with varying evaporator lengths based on pulse tube refrigerator

INTERNATIONAL JOURNAL OF REFRIGERATION

IF3.8

2023-01-018

OAAI

Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-12-169

PRE

段文虎 (Wenhu Duan)

个人简介

教育背景

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