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P

Philip Hinchliffe

University of Bristol
H指数:27
被引数:3,986

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Time-resolved ligand dynamics revealed in a β-lactamase using room-temperature serial crystallography

在β-内酰胺酶中利用室温串行晶体学揭示的时间分辨配体动力学

Communications Chemistry
IF6.2
2026-11-040
OAAI
Philip Hinchliffe; Catherine L. Tooke; Michael Beer; Pierre Aller; Jos J. A. G. Kamps; Laura Parkinson; Tiankun Zhou; Nicholas Devenish; Do-Heon Gu; Anastasya Shilova; Matthew J. Rodrigues; Abbey Telfer; Agata Butryn; Marko Hanževački; Emily I. Freeman; Sehan Park; Christopher J. Schofield; Jaehyun Park; Robin L. Owen; Adrian J. Mulholland; Allen M. Orville; James Spencer
A global survey of intramolecular isopeptide bonds

分子内异肽键的全球调查

PROTEIN SCIENCE
IF5.2
2025-11-140
OAAI
Costa, Francesco; Riziotis, Ioannis; Andreeva, Antonina; Kalwan, Delhi; De Jong, Jennifer; Hinchliffe, Philip; Parmeggiani, Fabio; Race, Paul R.; Burston, Steven G.; Bateman, Alex; Barringer, Rob
All Roads Lead to Carbinolamine: QM/MM Study of Enzymatic C-N Bond Cleavage in Anaerobic Glycyl Radical Enzyme Choline Trimethylamine-Lyase (CutC)

Hanzevacki, M.; Güven, J.J.; Hinchliffe, P.; Shaw, J.; Mey, A.S.J.S.; Fey, N.; Spencer, J.; Mulholland, A.J. 所有路径都指向卡宾醇胺：量子力学/分子力学（QM/MM）研究厌氧甘氨酸自由基酶胆碱三甲胺裂解酶（CutC）中的酶促C-N键断裂。J. Phys. Chem. B 2025, 129, 9322–9332. [Google Scholar] [CrossRef]

JOURNAL OF PHYSICAL CHEMISTRY B
IF2.9
2025-09-010
OAAI
Hanzevacki, Marko; Guven, J. Jasmin; Hinchliffe, Philip; Shaw, John; Mey, Antonia S. J. S.; Fey, Natalie; Spencer, James; Mulholland, Adrian J.
Dynamic Behavior and Substrate Interactions of the Polymyxin Resistance Determinant MCR-1 Investigated by Molecular Dynamics Simulations in the Membrane Environment

在膜环境中通过分子动力学模拟研究的MCR-1多黏菌素耐药决定因子的动态行为与底物相互作用

Journal of Chemical Information and Modeling
IF5.3
2025-07-220
PRE
Emily Lythell; Jack Badley; Reynier Suardíaz; Catherine R. Gurr; Catherine L. Tooke; Philip Hinchliffe; A. Sofia F. Oliveira; Marc W. Van der Kamp; James Spencer; Adrian J. Mulholland
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

模仿 β-内酰胺结合可实现广谱金属 β-内酰胺酶抑制剂

NATURE CHEMISTRY
IF20.2
2021-12-1342
PRE
Brem, Jurgen; Panduwawala, Tharindi; Hansen, Jon Ulf; Hewitt, Joanne; Liepins, Edgars; Donets, Pawel; Espina, Laura; Farley, Alistair J. M.; Shubin, Kirill; Campillos, Gonzalo Gomez; Kiuru, Paula; Shishodia, Shifali; Krahn, Daniel; Lesniak, Robert K.; Schmidt (Adrian), Juliane; Calvopina, Karina; Turrientes, Maria-Carmen; Kavanagh, Madeline E.; Lubriks, Dmitrijs; Hinchliffe, Philip; Langley, Gareth W.; Aboklaish, Ali F.; Eneroth, Anders; Backlund, Maria; Baran, Andrei G.; Nielsen, Elisabet, I; Speake, Michael; Kuka, Janis; Robinson, John; Grinberga, Solveiga; Robinson, Lindsay; McDonough, Michael A.; Rydzik, Anna M.; Leissing, Thomas M.; Jimenez-Castellanos, Juan Carlos; Avison, Matthew B.; Pinto, Solange Da Silva; Pannifer, Andrew D.; Martjuga, Marina; Widlake, Emma; Priede, Martins; Navratilova, Iva Hopkins; Gniadkowski, Marek; Belfrage, Anna Karin; Brandt, Peter; Yli-Kauhaluoma, Jari; Bacque, Eric; Page, Malcolm G. P.; Bjorkling, Fredrik; Tyrrell, Jonathan M.; Spencer, James; Lang, Pauline A.; Baranczewski, Pawel; Canton, Rafael; McElroy, Stuart P.; Jones, Philip S.; Baquero, Fernando; Suna, Edgars; Morrison, Angus; Walsh, Timothy R.; Schofield, Christopher J.
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
NATURE COMMUNICATIONS
IF15.7
2021-07-2241
OAAI
Butryn, Agata; Simon, Philipp S.; Aller, Pierre; Hinchliffe, Philip; Massad, Ramzi N.; Leen, Gabriel; Tooke, Catherine L.; Bogacz, Isabel; Kim, In-Sik; Bhowmick, Asmit; Brewster, Aaron S.; Devenish, Nicholas E.; Brem, Jurgen; Kamps, Jos J. A. G.; Lang, Pauline A.; Rabe, Patrick; Axford, Danny; Beale, John H.; Davy, Bradley; Ebrahim, Ali; Orlans, Julien; Storm, Selina L. S.; Zhou, Tiankun; Owada, Shigeki; Tanaka, Rie; Tono, Kensuke; Evans, Gwyndaf; Owen, Robin L.; Houle, Frances A.; Sauter, Nicholas K.; Schofield, Christopher J.; Spencer, James; Yachandra, Vittal K.; Yano, Junko; Kern, Jan F.; Orville, Allen M.

研究方向

暂未获取到该数据
J
James Spencer
H 指数:60论文数:326被引数:1.6万
C
Christopher J. Schofield
H 指数:112论文数:1,313被引数:6.2万
A
Adrian J. Mulholland
H 指数:71论文数:481被引数:1.6万
J
Jürgen Brem
H 指数:35论文数:148被引数:3,743
C
Catherine L. Tooke
H 指数:16论文数:44被引数:1,873
R
Robert A. Bonomo
H 指数:115论文数:1,144被引数:6.0万
A
Alejandro J. Vila
H 指数:52论文数:295被引数:9,081
M
María F. Mojica
H 指数:24论文数:84被引数:2,229
G
Graciela Mahler
H 指数:18论文数:77被引数:1,043
K
Karina Calvopiña
H 指数:15论文数:35被引数:696