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J

Julie Sanchez

national institutes of health
H指数:14
被引数:1,060

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The structure of the dopamine D3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology

多巴胺D3受体与卡利拉赞结合的结构揭示了具有设计药理学特性的部分激动剂的原则

Science Advances
IF12.5
2026-08-280
OA
Eliane Hadas Yardeni; Dóra Judit Kiss; Julie Sanchez; Keshet Shavit; Dénes Szepesi Kovács; Attila Egyed; Caleb D. Vogt; Supriya A. Gaitonde; Jacqueline Glenn; Meritxell Canals; Michel Bouvier; Amy Hauck Newman; J. Robert Lane; György M. Keserű; Moran Shalev-Benami
Dual-target mu opioid-dopamine D3 receptor (MOR-D3R) ligands based on etonitazene: New leads for transforming nitazenes into novel analgesics

基于依诺硝唑的双靶点μ阿片-多巴胺D3受体(MOR-D3R)配体：将硝唑类化合物转化为新型镇痛药的新先导化合物

European Journal of Medicinal Chemistry
IF5.9
2026-06-010
OAAI
Jahan, Khorshada; Glatfelter, Grant; Sanchez, Julie; Maitland, Alexander D.; Bonifazi, Alessandro; Saab, Elizabeth; Keegan, Bradley M.; Rais, Rana; Bi, Guo-Hua; Gomez, Juan L.; Michaelides, Michael; Xi, Zheng-Xiong; Lane, J. Robert; Canals, Meritxell; Baumann, Michael H.; Newman, Amy Hauck
Discovery of the First-in-Class Inhibitors of Hypoxia Up-Regulated Protein 1 (HYOU1) Suppressing Pathogenic Fibroblast Activation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2024-02-260
PRE
Papadopoulou, Dimitra; Mavrikaki, Vasiliki; Charalampous, Filippos; Tzaferis, Christos; Samiotaki, Martina; Papavasileiou, Konstantinos D.; Afantitis, Antreas; Karagianni, Niki; Denis, Maria C.; Sanchez, Julie; Lane, J. Robert; Faidon Brotzakis, Zacharias; Skretas, Georgios; Georgiadis, Dimitris; Matralis, Alexios N.; Kollias, George
Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics

双靶点多巴胺D3 (D3R) 和 μ-阿片 (MOR) 受体配体作为潜在更安全的镇痛药的药理和理化性质优化

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-07-196
OA
Bonifazi, Alessandro; Saab, Elizabeth; Sanchez, Julie; Nazarova, Antonina L.; Zaidi, Saheem A.; Jahan, Khorshada; Katritch, Vsevolod; Canals, Meritxell; Lane, J. Robert; Newman, Amy Hauck
Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders

基于Cariprazine的多巴胺D3/D2受体配体用于治疗可能被双重诊断为情感障碍的精神兴奋剂使用障碍

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-01-203
OA
Gogarnoiu, Emma S.; Vogt, Caleb D.; Sanchez, Julie; Bonifazi, Alessandro; Saab, Elizabeth; Shaik, Anver Basha; Soler-Cedeno, Omar; Bi, Guo-Hua; Klein, Benjamin; Xi, Zheng-Xiong; Lane, J. Robert; Newman, Amy Hauck
Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management

新型双靶点 μ-阿片受体和多巴胺D3受体配体作为疼痛治疗的潜在非成瘾性药物治疗

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-05-2018
OAAI
Bonifazi, Alessandro; Battiti, Francisco O.; Sanchez, Julie; Zaidi, Saheem A.; Bow, Eric; Makarova, Mariia; Cao, Jianjing; Shaik, Anver Basha; Sulima, Agnieszka; Rice, Kenner C.; Katritch, Vsevolod; Canals, Meritxell; Lane, J. Robert; Newman, Amy Hauck
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
SCIENCE SIGNALING
IF6.6
2020-03-31227
OA
Gillis, Alexander; Gondin, Arisbel B.; Kliewer, Andrea; Sanchez, Julie; Lim, Herman D.; Alamein, Claudia; Manandhar, Preeti; Santiago, Marina; Fritzwanker, Sebastian; Schmidel, Frank; Katte, Timothy A.; Reekie, Tristan; Grimsey, Natasha L.; Kassiou, Michael; Kellam, Barrie; Krasel, Cornelius; Halls, Michelle L.; Connor, Mark; Lane, J. Robert; Schulz, Stefan; Christie, Macdonald J.; Canals, Meritxell
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

发现赖氨酸乙酰转移酶的酰基磺酰肼衍生抑制剂KAT6A作为有效的衰老诱导抗癌剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-03-0214
PREAI
Priebbenow, Daniel L.; Leaver, David J.; Nghi Nguyen; Cleary, Benjamin; Lagiakos, H. Rachel; Sanchez, Julie; Xue, Lian; Huang, Fei; Sun, Yuxin; Mujumdar, Prashant; Mudududdla, Ramesh; Varghese, Swapna; Teguh, Silvia; Charman, Susan A.; White, Karen L.; Shackleford, David M.; Katneni, Kasiram; Cuellar, Matthew; Strasser, Jessica M.; Dahlin, Jayme L.; Walters, Michael A.; Street, Ian P.; Monahan, Brendon J.; Jarman, Kate E.; Sabroux, Helene Jousset; Falk, Hendrik; Chung, Matthew C.; Hermans, Stefan J.; Downer, Natalie L.; Parker, Michael W.; Voss, Anne K.; Thomas, Tim; Baell, Jonathan B.
Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-06-2925
PREAI
Leaver, David J.; Cleary, Benjamin; Nghi Nguyen; Priebbenow, Daniel L.; Lagiakos, H. Rachel; Sanchez, Julie; Xue, Lian; Huang, Fei; Sun, Yuxin; Mujumdar, Prashant; Mudududdla, Ramesh; Varghese, Swapna; Teguh, Silvia; Charman, Susan A.; White, Karen L.; Katneni, Kasiram; Cuellar, Matthew; Strasser, Jessica M.; Dahlin, Jayme L.; Walters, Michael A.; Street, Ian P.; Monahan, Brendon J.; Jarman, Kate E.; Sabroux, Helene Jousset; Falk, Hendrik; Chung, Matthew C.; Hermans, Stefan J.; Parker, Michael W.; Thomas, Tim; Baell, Jonathan B.

研究方向

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M
Meritxell Canals
H 指数:53论文数:156被引数:9,274
J
J. Robert Lane
H 指数:41论文数:138被引数:7,525
M
Martin J. Stone
H 指数:40论文数:151被引数:5,477
A
Amy Hauck Newman
H 指数:63论文数:418被引数:1.4万
A
Alessandro Bonifazi
H 指数:25论文数:116被引数:1,877
R
Richard J. Payne
H 指数:58论文数:349被引数:1.0万
E
Elizabeth Saab
H 指数:3论文数:8被引数:51
H
Herman D. Lim
H 指数:25论文数:45被引数:2,125
C
Caleb D. Vogt
H 指数:4论文数:6被引数:110
M
Michael A. Walters
H 指数:36论文数:225被引数:7,922