Boshi Huang

Shandong University

H指数:27

被引数:2,181

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β-Amyrin's Antidepressant-Like Activity in Mice and Zebrafish: Mechanistic Pathways and In Silico Molecular Interactions

β-amyrin 在小鼠和斑马鱼中的抗抑郁样活性：机制途径和计算机分子相互作用

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2025-03-010

PRE

Discovery of Brain-Penetrative Negative Allosteric Modulators of NMDA Receptors Using FEP-Guided Structure Optimization and Membrane Permeability Prediction

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2025-01-140

PRE

Discovery of novel fused-heterocycle-bearing diarypyrimidine derivatives as HIV-1 potent NNRTIs targeting tolerant region I for enhanced antiviral activity and resistance profile

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2025-01-011

PRE

Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-12-011

PRE

Discovery of GluN2A subtype-selective N-methyl-D-aspartate (NMDA) receptor ligands

ACTA PHARMACEUTICA SINICA B

IF14.6

2024-05-012

OAAI

NCP, a Dual Kappa and Mu Opioid Receptor Agonist, Is a Potent Analgesic Against Inflammatory Pain without Reinforcing or Aversive Properties

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2024-04-013

OAAI

Design, Synthesis, and Antisickling Investigation of a Thiazolidine Prodrug of TD-7 That Prolongs the Duration of Action of Antisickling Aromatic Aldehyde

PHARMACEUTICS

IF5.5

2023-10-280

OAAI

Discovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profiles

发现带有六元非芳族杂环的新型二芳基嘧啶衍生物作为有效的HIV-1 nnrti，具有改善的抗逆性和药物样特征

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-10-016

PRE

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors

发现带有哌嗪磺酰基的二芳基嘧啶衍生物作为有效的HIV-1非核苷类逆转录酶抑制剂

COMMUNICATIONS CHEMISTRY

IF6.2

2023-04-2912

OAAI

Quantitative assessment of the in-vitro binding kinetics of antisickling aromatic aldehydes with hemoglobin A: A universal HPLC-UV/Vis method to quantitate Schiff-base adduct formation

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

IF3.1

2023-01-011

OAAI

Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease

MOLECULES

IF4.6

2022-10-125

OAAI

Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives

教老狗新把戏: 通过重新定位天然产物及其衍生物来发现药物

DRUG DISCOVERY TODAY

IF7.5

2022-07-0135

OAAI

Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-03-0810

Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment

外周选择性 μ 阿片受体配体作为潜在阿片类药物诱导便秘治疗的合理设计、化学合成和生物学评价

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-03-084

Newly Emerging Strategies in Antiviral Drug Discovery: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Anniversary

MOLECULES

IF4.6

2022-01-2718

OAAI

Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-09-0912

Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity

基于结构的设计和开发靶向假定的MOR-CCR5异二聚体的化学探针，以抑制阿片类药物加剧的HIV-1感染性

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-05-2412

OAAI

Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-03-0120

OAAI

Design of bivalent ligands targeting putative GPCR dimers

DRUG DISCOVERY TODAY

IF7.5

2021-01-0136

OAAI

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

SCIENTIFIC REPORTS

IF3.9

2020-11-2019

OAAI

Boshi Huang

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