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D

Dongwei Kang

Shandong University
H指数:40
被引数:4,824

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Correction to “Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2; 4; 6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles”

“对《探索HIV-1逆转录酶p51/p66界面：基于结构的2; 4; 6-三取代嘧啶类新型非核苷逆转录酶抑制剂的设计与优化及其改进的抗药性谱》的更正”

Journal of Medicinal Chemistry
IF6.8
2025-10-230
OAAI
Xiangkai Ji; Xiangyi Jiang; Zhen Gao; Heng Gao; Xing Huang; Fabao Zhao; Erik De Clercq; Zhao Wang; Christophe Pannecouque; Dongwei Kang; Peng Zhan; Xinyong Liu
Structure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety Profiles

基于结构和特权片段的迭代优化: 发现2，4-二取代-6-氨基嘧啶作为新型HIV-1 nnrti，对耐药菌株具有有效活性和良好的安全性

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-10-010
PRE
Ji, Xiangkai; Jiang, Xiangyi; Gao, Heng; Gao, Zhen; De Clercq, Erik; Pannecouque, Christophe; Kang, Dongwei; Zhan, Peng; Liu, Xinyong
IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1

IRG1催化产生的能量代谢物衣康酸通过烷基化TBK1来抑制I型干扰素依赖的免疫应答。

Cell Reports
IF6.9
2025-09-260
PREAI
Li Chai; Chaoqun Li; Xuefeng Wang; Yanyang Qin; Hemin Sun; Jie Du; Liu Yang; Dongmei Hu; Jianan Xiong; Zhiyuan Zhao; Rong Gong; Tao Wu; Meng Wu; Meng Nie; Jialin Gao; Jihui Jia; Chengjiang Gao; Wei Zhao; Huan Zhou; Dongwei Kang; Mutian Jia
Design, synthesis, and biological evaluation of dual-site HIV-1 inhibitors simultaneously targeting the NNRTI binding pocket and an adjacent site with favorable resistance profiles

双位点HIV-1抑制剂的分子设计、合成及其生物活性评价：同时靶向NNRTI结合口袋及相邻位点，并表现出有利的耐药性谱。

Bioorganic Chemistry
IF4.7
2025-08-260
PRE
Xiangkai Ji; Xiangyi Jiang; Xing Huang; Heng Gao; Zhen Gao; Ping Gao; Erik De Clercq; Christophe Pannecouque; Dongwei Kang; Peng Zhan; Xinyong Liu
Further exploring the tolerant region II: Identification of 2,4,5-trisubstituted pyrimidines as HIV-1 reverse transcriptase allosteric inhibitors with desirable antiviral activities and reduced cytotoxicity

进一步探索耐受区域II：鉴定2,4,5-三取代嘧啶类作为具有理想抗病毒活性和降低细胞毒性的HIV-1逆转录酶别构抑制剂

European Journal of Medicinal Chemistry
IF5.9
2025-07-210
PRE
Zhenzhen Zhou; Lin Zheng; Wenbo Jiang; Wenbo Zhang; Fabao Zhao; Zhening Liang; Erik De Clercq; Christophe Pannecouque; Peng Zhan; Dongwei Kang; Xinyong Liu
Probing the Dominant Motifs within the Hydrophobic Channel Yields Oxadiazole-Containing Diarylpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

探查疏水通道中的优势基序产生含恶二唑的二芳基嘧啶衍生物，作为强效HIV-1非核苷类逆转录酶抑制剂

Journal of Medicinal Chemistry
IF6.8
2025-07-170
PRE
Tao Zhang; Yue Yang; Xin Li; Fabao Zhao; Zongji Zhuo; Le Wang; Wenbo Zhang; Erik De Clercq; Christophe Pannecouque; Peng Zhan; Dongwei Kang; Xinyong Liu

研究方向

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刘
刘新泳
H 指数:54论文数:427被引数:1.1万
展
展鹏
H 指数:51论文数:376被引数:1.0万
C
Christophe Pannecouque
H 指数:71论文数:757被引数:2.0万
E
Erik De Clercq
H 指数:162论文数:3,980被引数:14.4万
F
Fabao Zhao
H 指数:14论文数:67被引数:641
汪
汪昭
H 指数:18论文数:45被引数:807
B
Boshi Huang
H 指数:27论文数:81被引数:2,179
D
Da Feng
H 指数:15论文数:35被引数:711
X
Xiangyi Jiang
H 指数:15论文数:54被引数:903
P
Peng Zhan
H 指数:27论文数:114被引数:2,765