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Andrew S. Thompson

university of bath
H指数:30
被引数:3,091
浏览量:0

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Manufacture of the PI3K β-Sparing Inhibitor Taselisib. Part 1: Early-Stage Development Routes to the Bromobenzoxazepine Core
ORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
2019-03-067
PREAI
Remarchuk, Travis; Angelaud, Remy; Askin, David; Kumar, Archana; Thompson, Andrew S.; Cheng, Hua; Reichwein, John F.; Chen, Yanping; St-Jean, Frederic
Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2016-08-0126
OAAI
Nathubhai, Amit; Haikarainen, Teemu; Hayward, Penelope C.; Munoz-Descalzo, Silvia; Thompson, Andrew S.; Lloyd, Matthew D.; Lehtio, Lari; Threadgill, Michael D.
Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2015-09-0133
OAAI
Paine, Helen A.; Nathubhai, Amit; Woon, Esther C. Y.; Sunderland, Peter T.; Wood, Pauline J.; Mahon, Mary F.; Lloyd, Matthew D.; Thompson, Andrew S.; Haikarainen, Teemu; Narwal, Mohit; Lehtio, Lari; Threadgill, Michael D.
Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2015-07-0145
OAAI
Kumpan, Katerina; Nathubhai, Amit; Zhang, Chenlu; Wood, Pauline J.; Lloyd, Matthew D.; Thompson, Andrew S.; Haikarainen, Teemu; Lehtio, Lari; Threadgill, Michael D.
Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2015-07-013
OAAI
Twum, Elvis A.; Nathubhai, Amit; Wood, Pauline J.; Lloyd, Matthew D.; Thompson, Andrew S.; Threadgill, Michael D.
Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and-2 and their possible role in the chiral inversion of profens
BIOCHEMICAL PHARMACOLOGY
IF5.6
2013-12-0114
OAAI
Qu, Xiao; Allan, Amanda; Chui, Grace; Hutchings, Thomas J.; Jiao, Ping; Johnson, Lawrence; Leung, Wai Y.; Li, Portia K.; Steel, Georgina R.; Thompson, Andrew S.; Threadgill, Michael D.; Woodman, Timothy J.; Lloyd, Matthew D.
Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2013-10-1744
OAAI
Nathubhai, Amit; Wood, Pauline J.; Lloyd, Matthew D.; Thompson, Andrew S.; Threadgill, Michael D.
One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2013-09-0122
OAAI
Woon, Esther C. Y.; Sunderland, Peter T.; Paine, Helen A.; Lloyd, Matthew D.; Thompson, Andrew S.; Threadgill, Michael D.
Synthetic Process Development of BMS-599793 Including Azaindole Negishi Coupling on Kilogram Scale
ORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
2013-06-1120
PREAI
Pikul, Stanislaw; Cheng, Hua; Cheng, Allen; Huang, C. D.; Ke, Alex; Kuo, LungHuang; Thompson, Andrew; Wilder, Susan
5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2011-03-1856
OAAI
Sunderland, Peter T.; Woon, Esther C. Y.; Dhami, Archana; Bergin, Aoife B.; Mahon, Mary F.; Wood, Pauline J.; Jones, Louise A.; Tully, Sophie R.; Lloyd, Matthew D.; Thompson, Andrew S.; Javaid, Hashim; Martin, Niall M. B.; Threadgill, Michael D.
Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen
CHEMICAL COMMUNICATIONS
IF4.2
2011-01-0139
OAAI
Woodman, Timothy J.; Wood, Pauline J.; Thompson, Andrew S.; Hutchings, Thomas J.; Steel, Georgina R.; Jiao, Ping; Threadgill, Michael D.; Lloyd, Matthew D.
The Pyrrolobenzodiazepine Dimer SJG-136 Forms Sequence-Dependent Intrastrand DNA Cross-Links and Monoalkylated Adducts in Addition to Interstrand Cross-Links
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2009-09-02106
PREAI
Rahman, Khondaker M.; Thompson, Andrew S.; James, Colin H.; Narayanaswamy, Mathangi; Thurston, David E.
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock
BRITISH JOURNAL OF PHARMACOLOGY
IF7.7
2009-01-2997
OAAI
McDonald, MC; Mota-Filipe, H; Wright, JA; Abdelrahman, M; Threadgill, MD; Thompson, AS; Thiemermann, C
Suzuki-Miyaura approach to JNJ-26076713, an orally active tetrahydroquinoline-containing αVβ3/αVβ5 integrin antagonist.: Enantioselective synthesis and stereochemical studies
JOURNAL OF ORGANIC CHEMISTRY
IF3.6
2008-02-1623
PRE
Kinney, William A.; Teleha, Christopher A.; Thompson, Andrew S.; Newport, Maria; Hansen, Ryan; Ballentine, Scott; Ghosh, Shyamali; Mahan, Andrew; Grasa, Gabriela; Zanotti-Gerosa, Antonio; Dingenen, Jules; Schubert, Carsten; Zhou, Yong; Leo, Gregory C.; McComsey, David F.; Santulli, Rosemary J.; Maryanoff, Bruce E.
Formation of 3-aryl-5-nitroisocoumarins from 5-nitroisocoumarins and aromatic acyl chlorides under Friedel-Crafts conditions
JOURNAL OF ORGANIC CHEMISTRY
IF3.6
2007-08-237
PREAI
Sunderland, Peter T.; Thompson, Andrew S.; Threadgill, Michael D.
Structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium tuberculosis
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2007-07-0164
OAAI
El-Hamamsy, Mervat H. R. I.; Smith, Anthony W.; Thompson, Andrew S.; Threadgill, Michael D.
CORRECTION
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2004-05-191
PREAI
THOMPSON, A
DIRECT CONVERSION OF ACTIVATED ALCOHOLS TO AZIDES USING DIPHENYL PHOSPHORAZIDATE - A PRACTICAL ALTERNATIVE TO MITSUNOBU CONDITIONS
JOURNAL OF ORGANIC CHEMISTRY
IF3.6
2002-05-01317
PREAI
THOMPSON, AS; HUMPHREY, GR; DEMARCO, AM; MATHRE, DJ; GRABOWSKI, EJJ
TOTAL SYNTHESIS OF (-)-LAURENYNE - USE OF ACETAL-INITIATED CYCLIZATIONS TO PREPARE FUNCTIONALIZED 8-MEMBERED CYCLIC ETHERS
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2002-05-01148
PREAI
OVERMAN, LE; THOMPSON, AS
TOTAL SYNTHESIS OF MILBEMYCIN BETA-3
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2002-05-01129
PREAI
SMITH, AB; SCHOW, SR; BLOOM, JD; THOMPSON, AS; WINZENBERG, KN

研究方向

暂未获取到该数据
M
Matthew D. Lloyd
H 指数:35论文数:159被引数:3,744
M
Michael D. Threadgill
H 指数:0论文数:0被引数:0
P
Pauline J. Wood
H 指数:27论文数:86被引数:1,698
A
Amit Nathubhai
H 指数:13论文数:23被引数:471
P
Peter Sunderland
H 指数:8论文数:29被引数:189
E
Edward J. J. Grabowski
H 指数:50论文数:258被引数:8,149
D
David E. Thurston
H 指数:45论文数:341被引数:7,111
E
Esther C. Y. Woon
H 指数:26论文数:51被引数:3,027
T
T. Haikarainen
H 指数:22论文数:133被引数:1,798
L
Larry E. Overman
H 指数:93论文数:873被引数:3.2万