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W

Weixue Huang

Shanghai Institute of Organic Chemistry
H指数:16
被引数:816

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Discovery of YJZ5118: A Potent and Highly Selective Irreversible CDK12/13 Inhibitor with Synergistic Effects in Combination with Akt Inhibition

YJZ5118的发现：一种具有协同效应的强效且高度选择性的不可逆CDK12/13抑制剂，可与Akt抑制联合用药。

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-03-130
PRE
Yang, Jianzhang; Chang, Yu; Zhou, Kaijie; Huang, Weixue; Tien, Jean Ching-Yi; Zhang, Pujuan; Liu, Wenyan; Zhou, Licheng; Zhou, Yang; Ren, Xiaomei; Mannan, Rahul; Mahapatra, Somnath; Zhang, Yuping; Hamadeh, Rudana; Ervine, Grafton; Wang, Zhen; Wang, George Xiaoju; Chinnaiyan, Arul M.; Ding, Ke
Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

开发口服生物可利用的CDK12/13降解剂并通过AKT途径抑制诱导合成致死率

CELL REPORTS
IF6.9
2024-10-011
OAAI
Chang, Yu; Wang, Xiaoju; Yang, Jianzhang; Tien, Jean Ching-Yi; Mannan, Rahul; Cruz, Gabriel; Zhang, Yuping; Vo, Josh N.; Magnuson, Brian; Mahapatra, Somnath; Cho, Hanbyul; Dhanasekaran, Saravana Mohan; Wang, Cynthia; Wang, Zhen; Zhou, Licheng; Zhou, Kaijie; Zhou, Yang; Zhang, Pujuan; Huang, Weixue; Xiao, Lanbo; Liu, Weihuang Raymond; Hamadeh, Rudana; Su, Fengyun; Wang, Rui; Miner, Stephanie J.; Cao, Xuhong; Cheng, Yunhui; Mehra, Rohit; Ding, Ke; Chinnaiyan, Arul M.

研究方向

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丁克
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周凤涛 封面图
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