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J

Jenny Desantis

University of Perugia
H指数:19
被引数:1,210

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Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies

基于理性的D3R/GSK-3β双靶点导向配体的优化及其作为双相情感障碍潜在治疗药物的研究：设计、合成、X射线晶体学、分子动力学模拟、体外ADME及体内药代动力学研究

European Journal of Medicinal Chemistry
IF5.9
2025-06-250
PRE
R.M.C. Di Martino; D. Russo; I. Penna; S. Demuro; A. Dalle Vedove; R. Spagnuolo; G. Ottonello; S.M. Bertozzi; M. Summa; J. Desantis; A. Valeri; L. Pruccoli; S.K. Tripathi; A. Tarozzi; P. Storici; S. Girotto; R. Bertorelli; A. Armirotti; G. Cruciani; T. Bandiera; A. Cavalli; G. Bottegoni
Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity

降解SARS-CoV-2主要蛋白酶并具有广谱抗病毒活性的基于吲哚美辛的PROTACs的设计，合成和生物学评价

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-03-0110
OAAI
Desantis, Jenny; Bazzacco, Alessandro; Eleuteri, Michela; Tuci, Sara; Bianconi, Elisa; Macchiarulo, Antonio; Mercorelli, Beatrice; Loregian, Arianna; Goracci, Laura
Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2020-09-0120
PREAI
Nizi, Maria Giulia; Desantis, Jenny; Nakatani, Yoshio; Massari, Serena; Mazzarella, Maria Angela; Shetye, Gauri; Sabatini, Stefano; Barreca, Maria Letizia; Manfroni, Giuseppe; Felicetti, Tommaso; Rushton-Green, Rowena; Hards, Kiel; Latacz, Gniewomir; Satala, Grzegorz; Bojarski, Andrzej J.; Cecchetti, Violetta; Kolar, Michal H.; Handzlik, Jadwiga; Cook, Gregory M.; Franzblau, Scott G.; Tabarrini, Oriana

研究方向

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L
Laura Goracci
H 指数:38论文数:163被引数:3,847
O
Oriana Tabarrini
H 指数:38论文数:177被引数:4,241
S
Serena Massari
H 指数:30论文数:103被引数:2,230
G
Gabriele Cruciani
H 指数:61论文数:353被引数:1.3万
V
Violetta Cecchetti
H 指数:39论文数:192被引数:4,242
G
Giuseppe Manfroni
H 指数:32论文数:116被引数:2,498
S
Stefano Sabatini
H 指数:36论文数:156被引数:5,031
A
Arianna Loregian
H 指数:37论文数:144被引数:5,547
B
Beatrice Mercorelli
H 指数:25论文数:53被引数:2,083
C
Christophe Pannecouque
H 指数:71论文数:757被引数:2.0万