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M

Manthena V. S. Varma

pfizer inc.

51H指数
164论文数
7.9K被引数
收录论文 74
发表时间
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Untargeted Metabolomics Reveal New Endogenous Plasma Biomarkers Associated with CYP3A Inhibition in Humans靶向代谢组学揭示与人类CYP3A抑制相关的新型内源性血浆生物标志物
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2026-09-24
err0
PREAI
errSook Wah Yee; Eugene P. Kadar; Matthew A. Cerny; Manoli Vourvahis; Lloyd Wei Tat Tang; R. Scott Obach; Matthew D. Troutman; Manthena V. S. Varma
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err收藏
Physiologically Based Pharmacokinetic Modeling to Assess Transporter-Mediated Drug–Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray基于生理的药代动力学建模，用于评估转运体介导的药物-药物相互作用，以支持Zavegepant鼻喷雾剂的标签建议
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2026-09-05
err0
errOAAI
errAlice Ke; Ernesto Callegari; Manthena V.S. Varma; Mayur K Ladumor; Chieko Muto; Richard J. Bertz; Hannah M. Jones; Vaishali Sahasrabudhe; Jing Liu
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Cyclosporine A, a macrocyclic peptide, is transported by organic anion transporting polypeptide 1B1/1B3 at clinically relevant doses环孢素A，一种大环肽，在临床相关剂量下由有机阴离子转运多肽1B1/1B3转运
errDrug Metabolism and Disposition
IF4
err2026-08-01
err0
PREAI
errMathialagan, Sumathy; Yee, Sook Wah; Orozco, Christine C.; Gernhardt, Steven Scott; Yamaguchi, Emi; West, Mark A.; Sannino, Sara; Phillips, Tracy Brown; Sommese, Ruth F.; Tess, David A.; Varma, Manthena V. S.
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Evaluating the Utility and Constraints of the Competitive Counter Flow (CCF) Assay in OATP1B1 Substrate Profiling评估竞争性逆流（CCF）测定法在OATP1B1底物分析中的实用性与局限性
errThe AAPS Journal
IF0
err2026-05-06
err0
PREAI
errSumathy Mathialagan; Mark A. West; Emi Yamaguchi; Hannah M. Moulton; Brendon Kapinos; Sasan Paryad Zanjani; David A. Tess; Emi Kimoto; Manthena V. S. Varma; Sook Wah Yee
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Biodistribution of Cerivastatin, Repaglinide, Glyburide, Rosuvastatin, and Valsartan in Cynomolgus Monkeys and PBPK Analysis西立伐他汀、吡格列酮、格列本脲、罗苏伐他汀和缬沙坦在狨猴中的生物分布及PBPK分析
errThe AAPS Journal
IF0
err2026-04-08
err0
PREAI
errRui Li; Samantha Jordan; Mark Niosi; Manthena V. S. Varma; Li Di
err分享
err收藏
Comparative Study of Absorption Prediction Using Human Intestinal Organoid-Derived Cells in Static and flow Conditions静态和流动条件下使用源自人肠道类器官细胞的吸收预测比较研究
errDrug Metabolism and Disposition
IF4
err2026-04-01
err0
PREAI
errQianying Yuan; Julie Harney; James E. Finley; Xiaofeng Wu; Hannah M. Moulton; Brendon Kapinos; Emi Yamaguchi; Ashley Griffith; Manthena V.S. Varma; Anna K. Kopec; Thomas Schroeter
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Comparative Analysis of Isavuconazole DDIs With Other Azole Antifungal Drugs and PBPK Model-Informed Dosing Recommendations for Anticancer Drugs伊曲康唑DDIs与其他唑类抗真菌药物的对比分析及基于PBPK模型的抗癌药物剂量推荐
errCPT: Pharmacometrics & Systems Pharmacology
IF0
err2025-10-17
err0
errOAAI
errTheunis C. Goosen; Xiaofeng Wu; Jian Lin; Narayan Cheruvu; Susan R. Raber; Maria Lavinea Novis de Figueiredo; Manthena V. S. Varma
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Hepatic Impairment and the Differential Effects on Drug Clearance Mechanisms: Analysis of Pharmacokinetic Changes in Disease State肝功能损伤及对药物清除机制的不同影响：疾病状态下药代动力学变化的分析
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2025-03-26
err0
PREAI
errLloyd Wei Tat Tang; Manthena V. S. Varma
err分享
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Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug-Drug Interactions吡啶酸作为肾有机阴离子转运蛋白活性的内源性生物标志物: 预测药物-药物相互作用的群体变异性和机制模型
errCPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
IF3
err2025-02-24
err0
errOAAI
errThakur, Aarzoo; Mathialagan, Sumathy; Kimoto, Emi; Varma, Manthena V. S.
err分享
err收藏
Navigating the Challenges of Cyclosporine as an Alternative to Rifampicin as an OATP1B Index Inhibitor
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2025-01-14
err0
PREAI
errVarma, Manthena V. S.; Vourvahis, Manoli
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Positioning Enzyme- and Transporter-Based Precipitant Drug-Drug Interaction Studies in Drug Design定位基于酶和转运体的沉淀物药物-药物相互作用研究在药物设计中的位置
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-01-06
err0
PREAI
errSchroeter, Thomas; Lapham, Kimberly; Varma, Manthena V. S.; Obach, R. Scott
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Mechanistic Determinants of Daprodustat Drug-Drug Interactions and Pharmacokinetics in Hepatic Dysfunction and Chronic Kidney Disease: Significance of OATP1B-CYP2C8 Interplay
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2024-02-26
err3
PREAI
errBi, Yi-An; Jordan, Samantha; King-Ahmad, Amanda; West, Mark A.; Varma, Manthena V. S.
err分享
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Membrane transporters in drug development and as determinants of precision medicine药物开发中的膜转运蛋白和精准医学的决定因素
errNATURE REVIEWS DRUG DISCOVERY
IF101.8
err2024-01-24
err38
PREAI
errGaletin, Aleksandra; Brouwer, Kim L. R.; Tweedie, Donald; Yoshida, Kenta; Sjostedt, Noora; Aleksunes, Lauren; Chu, Xiaoyan; Evers, Raymond; Hafey, Michael J.; Lai, Yurong; Matsson, Par; Riselli, Andrew; Shen, Hong; Sparreboom, Alex; Varma, Manthena V. S.; Yang, Jia; Yang, Xinning; Yee, Sook Wah; Zamek-Gliszczynski, Maciej J.; Zhang, Lei; Giacomini, Kathleen M.
err分享
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Significance of Organic Anion Transporter 2 and Organic Cation Transporter 2 in Creatinine Clearance: Mechanistic Evaluation Using Freshly Prepared Human Primary Renal Proximal Tubule Cells
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2024-01-01
err1
errOAAI
errMathialagan, Sumathy; Chung, Git; Pye, Keith; Rodrigues, A. David; Varma, Manthena V. S.; Brown, Colin
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Utilization of OATP1B Biomarker Coproporphyrin-I to Guide Drug-Drug Interaction Risk Assessment: Evaluation by the Pharmaceutical Industry
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2023-10-11
err17
PREAI
errKikuchi, Ryota; Chothe, Paresh P.; Chu, Xiaoyan; Huth, Felix; Ishida, Kazuya; Ishiguro, Naoki; Jiang, Rongrong; Shen, Hong; Stahl, Simone H.; Varma, Manthena V. S.; Willemin, Marie-Emilie; Morse, Bridget L.
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Translatability of in vitro Inhibition Potency to in vivo P-Glycoprotein Mediated Drug Interaction Risk
errJOURNAL OF PHARMACEUTICAL SCIENCES
IF3.8
err2023-06-01
err6
PREAI
errLazzaro, Sarah; West, Mark A.; Eatemadpour, Soraya; Feng, Bo; Varma, Manthena V. S.; Rodrigues, A. David; Temesszentandrasi-Ambrus, Csilla; Kovacs-Hajdu, Peter; Nerada, Zsuzsanna; Gaborik, Zsuzsanna; Costales, Chester
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Genetic variation in organic cation transporters and considerations in drug development
errEXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
IF3.4
err2023-04-23
err4
PREAI
errVarma, Manthena V. S.
err分享
err收藏
Effect of Hepatic Impairment on OATP1B Activity: Quantitative Pharmacokinetic Analysis of Endogenous Biomarker and Substrate Drugs
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2023-01-15
err21
PREAI
errLin, Jian; Kimoto, Emi; Yamazaki, Shinji; Vourvahis, Manoli; Bergman, Arthur; Rodrigues, A. David; Costales, Chester; Li, Rui; Varma, Manthena V. S.
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err收藏
Identification of Organic Anion Transporter 2 Inhibitors: Screening, Structure-Based Analysis, and Clinical Drug Interaction Risk Assessment
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-10-21
err3
PREAI
errRyu, Sangwoo; Woody, Nathaniel; Chang, George; Mathialagan, Sumathy; Varma, Manthena V. S.
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Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2022-06-29
err37
PREAI
errZamek-Gliszczynski, Maciej J.; Sangha, Vishal; Shen, Hong; Feng, Bo; Wittwer, Matthias B.; Varma, Manthena V. S.; Liang, Xiaomin; Sugiyama, Yuichi; Zhang, Lei; Bendayan, Reina
err分享
err收藏

研究方向

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合作学者
合作期刊
Y
Yuichi Sugiyama
H 指数: 112 · 论文数: 1.1K
A
Alex Sparreboom
H 指数: 98 · 论文数: 842
J
Jennifer Dressman
H 指数: 85 · 论文数: 402
H
Hiroyuki Kusuhara
H 指数: 84 · 论文数: 456
R
R. Scott Obach
H 指数: 83 · 论文数: 304
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