logo
CanyamAI summaries for academic research
language
MobileMobile
  • Phone FeatureWeChat Mini Program
EnglishEnglish
noticeNotice
BlogBlog
delete
arrow
Back
T

Thazha P. Prakash

ionis pharmaceuticals inc.

51H-index
141Paper Count
8.1KCitation Count
Published Papers 82
Publication Date
logo
Enhanced splicing modulation by NMA-modified antisense oligonucleotides
errNucleic Acids Research
IF13.1
err2026-05-21
err0
errOAAI
errKaren Ling; Thazha P Prakash; Jinghua Yu; Michaela Jackson; Seung J Chun; Gemma Bachmann; Noah Post; Sarah Greenlee; Armand Soriano; John L Hunyara; Daniel A Norris; Paymaan Jafar-nejad; Eric E Swayze; C Frank Bennett; Frank Rigo
errShare
errSave
Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-11-11
err0
PREAI
errPrakash, Thazha P.; Mullick, Adam E.; Riney, Stan; Yu, Jinghua; Nikan, Mehran; Quirk, Clare; Crutchfield, Amanda; Damle, Sagar S.; Klein, Stephanie; Swayze, Eric E.
errShare
errSave
The protein deacetylase SIRT2 exerts metabolic control over adaptive J3 cell proliferation
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-10-01
err1
errOAAI
errWortham, Matthew; Ramms, Bastian; Zeng, Chun; Benthuysen, Jacqueline R.; Sai, Somesh; Pollow, Dennis P.; Liu, Fenfen; Schlichting, Michael; Harrington, Austin R.; Liu, Bradley; Prakash, Thazha P.; Pirie, Elaine C.; Zhu, Han; Baghdasarian, Siyouneh; Lee, Sean T.; Ruthig, Victor A.; Wells, Kristen L.; Auwerx, Johan; Shirihai, Orian S.; Sander, Maike
errShare
errSave
Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-08-12
err0
PREAI
errNikan, Mehran; Li, Qingfeng; Tanowitz, Michael; Li, Hongda; Damle, Sagar; Annoual, Marie; Galindo-Murillo, Rodrigo; Low, Audrey; Klein, Stephanie; Quirk, Clare; Vasquez, Guillermo; Wan, W. Brad; Watt, Andrew T.; Migawa, Michael T.; Swayze, Eric E.; Prakash, Thazha P.
errShare
errSave
Antisense oligonucleotide therapy for patients with Friedreich’s ataxia carrying the c.165+5G>C splicing mutation
errMolecular Therapy Nucleic Acids
IF6.1
err2025-07-01
err0
errOAAI
errPouiré Yameogo; Selina Aguilar; Thazha P. Prakash; Frank Rigo; David R. Lynch; Jill S. Napierala; Marek Napierala
errShare
errSave
Anti-TNF-α antisense-oligonucleotide-conjugated PLG nanoparticles protect transplanted islets
errMolecular Therapy Methods & Clinical Development
IF4.7
err2025-05-14
err0
errOAAI
errElizabeth J. Bealer; Namit Padgaonkar; Kelly Crumley; Eiji Saito; Zoe Beekman; Alexa DeKorte; Thazha P. Prakash; Alexey Revenko; Lonnie D. Shea
errShare
errSave
GalNAc-conjugated siRNA targeting the DNAJB1-PRKACA fusion junction in fibrolamellar hepatocellular carcinoma
errMOLECULAR THERAPY
IF12
err2024-01-01
err3
errOAAI
errNeumayer, Christoph; Ng, Denise; Requena, David; Jiang, Caroline S.; Qureshi, Adam; Vaughan, Roger; Prakash, Thazha P.; Revenko, Alexey; Simon, Sanford M.
errShare
errSave
Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide
errFRONTIERS IN MOLECULAR BIOSCIENCES
IF4
err2023-02-06
err3
errOAAI
errGurlo, Tatyana; Prakash, Thazha P.; Wang, Zhongying; Archang, Maani; Pei, Lina; Rosenberger, Madeline; Pirie, Elaine; Lee, Richard G.; Butler, Peter C.
errShare
errSave
Premature transcription termination at the expanded GAA repeats and aberrant alternative polyadenylation contributes to the Frataxin transcriptional deficit in Friedreich's ataxia
errHUMAN MOLECULAR GENETICS
IF3.2
err2022-06-16
err10
errOAAI
errLi, Yanjie; Li, Jixue; Wang, Jun; Zhang, Siyuan; Giles, Keith; Prakash, Thazha P.; Rigo, Frank; Napierala, Jill S.; Napierala, Marek
errShare
errSave
Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2021-07-28
err47
errOAAI
errYong, Jing; Parekh, Vishal S.; Reilly, Shannon M.; Nayak, Jonamani; Chen, Zhouji; Lebeaupin, Cynthia; Jang, Insook; Zhang, Jiangwei; Prakash, Thazha P.; Sun, Hong; Murray, Sue; Guo, Shuling; Ayala, Julio E.; Satin, Leslie S.; Saltiel, Alan R.; Kaufman, Randal J.
errShare
errSave
Overcoming the challenges of tissue delivery for oligonucleotide therapeutics
errTRENDS IN PHARMACOLOGICAL SCIENCES
IF19.9
err2021-07-01
err53
PREAI
errGokirmak, Tufan; Nikan, Mehran; Wiechmann, Svenja; Prakash, Thazha P.; Tanowitz, Michael; Seth, Punit P.
errShare
errSave
Site-specific Incorporation of 2′,5′-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2021-04-05
err12
errOAAI
errPrakash, Thazha P.; Yu, Jinghua; Shen, Wen; De Hoyos, Cheryl Li; Berdeja, Andres; Gaus, Hans; Liang, Xue-hai; Crooke, Stanley T.; Seth, Punit P.
errShare
errSave
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2021-02-24
err40
PREAI
errKnerr, Laurent; Prakash, Thazha P.; Lee, Richard; Drury, William J., III; Nikan, Mehran; Fu, Wuxia; Pirie, Elaine; De Maria, Leonardo; Valeur, Eric; Hayen, Ahlke; Olwegard-Halvarsson, Maria; Broddefalk, Johan; Ammala, Carina; Ostergaard, Michael E.; Meuller, Johan; Sundstrom, Linda; Andersson, Patrik; Janzen, David; Jansson-Lofmark, Rasmus; Seth, Punit P.; Andersson, Shalini
errShare
errSave
Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs
errNUCLEIC ACIDS RESEARCH
IF13.1
err2021-02-05
err32
errOAAI
errVasquez, Guillermo; Freestone, Graeme C.; Wan, W. Brad; Low, Audrey; Li De Hoyos, Cheryl; Yu, Jinghua; Prakash, Thazha P.; Ostergaard, Michael E.; Liang, Xue-hai; Crooke, Stanley T.; Swayze, Eric E.; Migawa, Michael T.; Seth, Punit P.
errShare
errSave
Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptides
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2020-07-17
err29
PREAI
errNikan, Mehran; Tanowitz, Michael; Dwyer, Chrissa A.; Jackson, Michaela; Gaus, Hans J.; Swayze, Eric E.; Rigo, Frank; Seth, Punit P.; Prakash, Thazha P.
errShare
errSave
Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice
errNUCLEIC ACIDS RESEARCH
IF13.1
err2020-03-17
err39
errOAAI
errChappell, Alfred E.; Gaus, Hans J.; Berdeja, Andres; Gupta, Ruchi; Jo, Minji; Prakash, Thazha P.; Oestergaard, Michael; Swayze, Eric E.; Seth, Punit P.
errShare
errSave
Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2019-10-01
err57
PREAI
errWang, Shiyu; Allen, Nickolas; Prakash, Thazha P.; Liang, Xue-hai; Crooke, Stanley T.
errShare
errSave
Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1
errNUCLEIC ACIDS RESEARCH
IF13.1
err2019-09-09
err29
errOAAI
errVickers, Timothy A.; Randar, Meghdad; Prakash, Thazha P.; Crooke, Stanley T.
errShare
errSave
Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models
errMOLECULAR THERAPY
IF12
err2019-09-01
err47
errOAAI
errKim, Youngsoo; Jo, Minji; Schmidt, Joanna; Luo, Xiaolin; Prakash, Thazha P.; Zhou, Tianyuan; Klein, Stephanie; Xiao, Xiaokun; Post, Noah; Yin, Zhengfeng; MacLeod, A. Robert
errShare
errSave
Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle
errNUCLEIC ACIDS RESEARCH
IF13.1
err2019-05-25
err104
errOAAI
errPrakash, Thazha P.; Mullick, Adam E.; Lee, Richard G.; Yu, Jinghua; Yeh, Steve T.; Low, Audrey; Chappell, Alfred E.; Ostergaard, Michael E.; Murray, Sue; Gaus, Hans J.; Swayze, Eric E.; Seth, Punit P.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
王
王军 (Jun Wang)
H-index: 222 · Papers: 3.2K
J
Johan Auwerx
H-index: 183 · Papers: 913
D
Don W. Cleveland
H-index: 165 · Papers: 525
R
Randal J. Kaufman
H-index: 158 · Papers: 639
A
Alan R. Saltiel
H-index: 107 · Papers: 387
View more