Not logged inSAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease
Colarusso, Stefania; Ferrigno, Federica; Ponzi, Simona; Pavone, Francesca; Conte, Immacolata; Abate, Luigi; Beghetto, Elisa; Missineo, Antonino; Amaudrut, Jerome; Bresciani, Alberto; Paonessa, Giacomo; Tomei, Licia; Montalbetti, Christian; Bianchi, Elisabetta; Toniatti, Carlo; Ontoria, Jesus M. M. .png)
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SaveDevelopment of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of PainAdams, Gregory L.; Pall, Parul S.; Grauer, Steven M.; Zhou, Xiaoping; Ballard, Jeanine E.; Vavrek, Marissa; Kraus, Richard L.; Morissette, Pierre; Li, Nianyu; Colarusso, Stefania; Bianchi, Elisabetta; Palani, Anandan; Klein, Rebecca; John, Christopher T.; Wang, Deping; Tudor, Matthew; Nolting, Andrew F.; Biba, Mirlinda; Nowak, Timothy; Makarov, Alexey A.; Reibarkh, Mikhail; Buevich, Alexei, V; Zhong, Wendy; Regalado, Erik L.; Wang, Xiao; Gao, Qi; Shahripour, Aurash; Zhu, Yuping; de Simone, Daniele; Frattarelli, Tommaso; Pasquini, Nicolo' Maria; Magotti, Paola; Iaccarino, Roberto; Li, Yuxing; Solly, Kelli; Lee, Keun-Joong; Wang, Weixun; Chen, Feifei; Zeng, Haoyu; Wang, Jixin; Regan, Hilary; Amin, Rupesh P.; Regan, Christopher P.; Burgey, Christopher S.; Henze, Darrell A.; Sun, Chengzao; Tellers, David M. Share Save Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide InhibitorMorissette, Pierre; Li, Nianyu; Ballard, Jeanine E.; Vavrek, Marissa; Adams, Gregory L.; Regan, Chris; Regan, Hillary; Lee, K. J.; Wang, Weixun; Burton, Aimee; Chen, Feifei; Gerenser, Pamela; Li, Yuxing; Kraus, Richard L.; Tellers, David; Palani, Anand; Zhu, Yuping; Sun, Chengzao; Bianchi, Elisabetta; Colarusso, Stefania; De Simone, Daniele; Frattarelli, Tommaso; Pasquini, Nicolo' Maria; Amin, Rupesh P. Share Save Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interactionColarusso, Stefania; De Simone, Daniele; Frattarelli, Tommaso; Andreini, Matteo; Cerretani, Mauro; Missineo, Antonino; Moretti, Daniele; Tambone, Sara; Kempf, Georg; Augustin, Martin; Steinbacher, Stefan; Munoz-Sanjuan, Ignacio; Park, Larry; Summa, Vincenzo; Tomei, Licia; Bresciani, Alberto; Dominguez, Celia; Toledo-Sherman, Leticia; Bianchi, Elisabetta Share Save Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 InteractionOntoria, Jesus M.; Biancofiore, Ilaria; Fezzardi, Paola; Ferrigno, Federica; Torrente, Esther; Colarusso, Stefania; Bianchi, Elisabetta; Andreini, Matteo; Patsilinakos, Alexandros; Kempf, Georg; Augustin, Martin; Steinbacher, Stefan; Summa, Vincenzo; Pacifici, Robert; Munoz-Sanjuan, Ignacio; Park, Larry; Bresciani, Alberto; Dominguez, Celia; Sherman, Leticia Toledo; Harper, Steven Share Save Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B PolymeraseNarjes, Frank; Crescenzi, Benedetta; Ferrara, Marco; Habermann, Jorg; Colarusso, Stefania; Ferreira, Maria del Rosario Rico; Stansfield, Ian; Mackay, Angela Claire; Conte, Immacolata; Ercolani, Caterina; Zaramella, Simone; Palumbi, Maria-Cecilia; Meuleman, Philip; Leroux-Roels, Geert; Giuliano, Claudio; Fiore, Fabrizio; Di Marco, Stefania; Baiocco, Paola; Koch, Uwe; Migliaccio, Giovanni; Altamura, Sergio; Laufer, Ralph; De Francesco, Raffaele; Rowley, Michael Share Save Optimization of Thienopyrrole-Based Finger-Loop Inhibitors of the Hepatitis C Virus NS5B PolymeraseHernando, Jose Ignacio Martin; Ontoria, Jesus Maria; Malancona, Savina; Attenni, Barbara; Fiore, Fabrizio; Bonelli, Fabio; Koch, Uwe; Di Marco, Stefania; Colarusso, Stefania; Ponzi, Simona; Gennari, Nadia; Vignetti, Sue Ellen; Ferreira, Maria del Rosario Rico; Habermann, Joerg; Rowley, Michael; Narjes, Frank Share Save 2-(2-thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: Discovery, SAR, modeling, and mutagenesisKoch, U; Attenni, B; Malancona, S; Colarusso, S; Conte, I; Di Filippo, M; Harper, S; Pacini, B; Giomini, C; Thomas, S; Incitti, I; Tomei, L; De Francesco, R; Altamura, S; Matassa, VG; Narjes, F Share Save Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease:: Discovery, initial SAR, and molecular modelingColarusso, S; Koch, U; Gerlach, B; Steinkühler, C; De Francesco, R; Altamura, S; Matassa, VG; Narjes, F Share Save Share Save 
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