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D

Darren W. Engers

Vanderbilt University School of Medicine
H指数:29
被引数:2,215

个人简介

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教育背景

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工作经历

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荣誉奖项

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Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent; Selective; and CNS-Penetrant Agonists for the Cannabinoid Receptor 2
Journal of Medicinal Chemistry
IF6.8
2026-02-050
OA
Daniel H. Haymer; Renn A. Duncan; Alice L. Rodriguez; Allie Han; Richard J. Lindsay; N. Kithmini Wijesiri; Analisa Thompson Gray; Srinivasan Krishnan; Aidong Qi; Benjamin P. Brown; Olivier Boutaud; Darren W. Engers; Carrie K. Jones; Colleen M. Niswender; Craig W. Lindsley; Aaron M. Bender
Discovery of VU6025733 (AG06827): A Highly Selective; Orally Bioavailable; and Structurally Distinct M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy
ACS Chemical Neuroscience
IF3.9
2026-01-250
OAAI
Alison R. Gregro; Charlotte Park; Madeline F. Long; Logan A. Baker; Katrina A. Bollinger; Anna E. Ringuette; Li Peng; Vincent B. Luscombe; Natasha B. Billard; Alice L. Rodriguez; Colleen M. Niswender; Weimin Peng; Jonathan W. Dickerson; Jerri M. Rook; Jordan O’Neill; Sichen Chang; Harrie C. M. Boonen; Thomas Jensen; Morten S. Thomsen; Thomas M. Bridges; Olivier Boutaud; P. Jeffrey Conn; Darren W. Engers; Craig W. Lindsley; Kayla J. Temple
Discovery of VU6052254: A Novel; Potent M1 Positive Allosteric Modulator

VU6052254的发现：一种新型的强效M1正向别构调节剂

ACS Chemical Neuroscience
IF3.9
2025-11-260
OAAI
Julie L. Engers; Joseph D. Bungard; Christopher C. Presley; Irene Zagol-Ikapitte; Katherine J. Watson; Sichen Chang; Colin O’Carroll; P. Markus Dey; Ethan S. Burstein; Jonathan W. Dickerson; Analisa Thompson Gray; Michael Bubser; Jerri M. Rook; Hyekyung P. Cho; Valerie M. Kramlinger; Olivier Boutaud; Carrie K. Jones; P. Jeffrey Conn; Darren W. Engers; Craig W. Lindsley
Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-10-010
PRE
Tanaka, Motoyuki; Sekioka, Yoko; Hashimoto, Gakuji; Mori, Takahiro; Shono, Tomoyuki; Isaji, Yuuki; Hisaichi, Katsuya; Childress, Elizabeth S.; Bollinger, Sean; Schmitt, Joza A.; Chopko, Trevor C.; Garrison, Aaron T.; Perry, Charles K.; Chronister, Keagan; Kramer, Meghan; Chang, Sichen; Watson, Katherine J.; Dickerson, Jonathan W.; Bubser, Michael; Rook, Jerri M.; Jones, Carrie K.; Boutaud, Olivier; Bridges, Thomas M.; Denton, Jerod S.; Engers, Darren W.; Kurata, Haruto; Lindsley, Craig W.
Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound

ONO-2920632 (VU6011887)的发现：一种具有高度选择性且可穿透中枢神经系统的、偏向性激活TREK-2 (TWIK-Related K+ Channel 2)的在体工具化合物

ACS CHEMICAL NEUROSCIENCE
IF0
2025-02-211
OA
Yashiro, K; Iwaki, Y; Urata, H; Kokubo, M; Mori, T; Sekioka, Y; Isami, K; Kato, J; Wieting, J; Mcgowan, KM; Bridges, TM; Boutaud, O; Engers, DW; Denton, JS; Kurata, H; Lindsley, CW
Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)
ACS CHEMICAL NEUROSCIENCE
IF3.9
2024-09-240
OAAI
Engers, Julie L.; Baker, Logan A.; Chang, Sichen; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Cho, Hyekyung P.; Bubser, Michael; Gray, Analisa Thompson; Jones, Carrie K.; Peng, Weimin; Rook, Jerri M.; Bridges, Thomas M.; Boutaud, Olivier; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.; Temple, Kayla J.
Discovery of VU6007496: Challenges in the Development of an M1 Positive Allosteric Modulator Backup Candidate
ACS CHEMICAL NEUROSCIENCE
IF3.9
2024-08-282
OAAI
Engers, Julie L.; Bollinger, Katrina A.; Capstick, Rory A.; Long, Madeline F.; Bender, Aaron M.; Dickerson, Jonathan W.; Peng, Weimin; Presley, Christopher C.; Cho, Hyekyung P.; Rodriguez, Alice L.; Niswender, Colleen M.; Moran, Sean P.; Xiang, Zixiu; Blobaum, Anna L.; Boutaud, Olivier; Rook, Jerri M.; Engers, Darren W.; Conn, P. Jeffrey; Lindsley, Craig W.
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2021-08-029
OA
Spock, Matthew; Carter, Trever R.; Bollinger, Katrina A.; Han, Changho; Baker, Logan A.; Rodriguez, Alice L.; Peng, Li; Dickerson, Jonathan W.; Qi, Aidong; Rook, Jerri M.; O'Neill, Jordan C.; Watson, Katherine J.; Chang, Sichen; Bridges, Thomas M.; Engers, Julie L.; Engers, Darren W.; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.; Bender, Aaron M.
Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu7 Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-01-0426
OAAI
Reed, Carson W.; Yohn, Samantha E.; Washecheck, Jordan P.; Roenfanz, Hanna F.; Quitalig, Marc C.; Luscombe, Vincent B.; Jenkins, Matthew T.; Rodriguez, Alice L.; Engers, Darren W.; Blobaum, Anna L.; Conn, P. Jeffrey; Niswender, Colleen M.; Lindsley, Craig W.
Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2018-10-1620
OAAI
Panarese, Joseph D.; Engers, Darren W.; Wu, Yong-Jin; Bronson, Joanne J.; Macor, John E.; Chun, Aspen; Rodriguez, Alice L.; Felts, Andrew S.; Engers, Julie L.; Loch, Matthew T.; Emmitte, Kyle A.; Castelhano, Arlindo L.; Kates, Michael J.; Nader, Michael A.; Jones, Carrie K.; Blobaurn, Anna L.; Conn, P. Jeffrey; Niswender, Colleen M.; Hopkins, Corey R.; Lindsley, Craig W.
Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1H-Pyrazolo[4,3-b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-09-2422
PREAI
Bollinger, Sean R.; Engers, Darren W.; Panarese, Joseph D.; West, Mary; Engers, Julie L.; Loch, Matthew T.; Rodriguez, Alice L.; Blobaum, Anna L.; Jones, Carrie K.; Gray, Analisa Thompson; Conn, P. Jeffrey; Lindsley, Craig W.; Niswender, Colleen M.; Hopkins, Corey R.

研究方向

暂未获取到该数据
C
Craig W. Lindsley
H 指数:86论文数:1,460被引数:3.0万
C
Colleen M. Niswender
H 指数:55论文数:406被引数:1.2万
P
P. Jeffrey Conn
H 指数:97论文数:684被引数:3.7万
A
Alice L. Rodriguez
H 指数:36论文数:164被引数:4,135
C
Carrie K. Jones
H 指数:53论文数:271被引数:8,553
C
Corey R. Hopkins
H 指数:44论文数:281被引数:5,822
A
Anna L. Blobaum
H 指数:34论文数:140被引数:3,405
J
Julie L. Engers
H 指数:18论文数:171被引数:933
O
Olivier Boutaud
H 指数:38论文数:170被引数:4,178
J
Jonathan W. Dickerson
H 指数:18论文数:44被引数:1,036