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张

张健存 (Jiancun Zhang)

chemical biology and drug discovery

H指数:28

被引数:3,023

个人简介

1980-1984年复旦大学学士，1984-1985年中山大学英语培训中心英语培训，1985-1990年美国University of Pittsburgh有机化学博士。1990-1992年Duke大学博士后。1992-2001年Gilead Sciences公司资深科学家。2000-2004年上海交通大学药学院教授。2002-2004年清华源兴生物医药与科技公司首席科学官。2005年至今中国科学院广州生物医药与健康研究院研究员。

教育背景

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工作经历

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荣誉奖项

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Structure-Based Virtual Screening of New Skp1 Inhibitor Chemotypes Targeting F-Box Binding Interface

基于结构的虚拟筛选：靶向F-Box结合界面的新型Skp1抑制剂化学骨架

drug design; development and therapy

IF0

2026-03-300

OAAI

Design, synthesis, and biological evaluation of novel 6-aminoalkyl- and 7-heteroaryl substituted 7-deazapurine nucleoside analogs against SARS-CoV-2 Replication

新型6-氨基烷基-和7-杂芳基取代的7-脱氮嘌呤核苷类似物的设计、合成及抗SARS-CoV-2复制的生物活性评价

Antiviral Research

IF4

2025-08-050

PRE

Long-Lasting Protection and Dose Optimization of MPXV Polyvalent Mpox mRNA Vaccines Against Lethal Vaccinia Virus Challenge in Mice

MPXV多价Mpox mRNA疫苗对小鼠致死性痘苗病毒攻击的长效保护及剂量优化

JOURNAL OF MEDICAL VIROLOGY

IF4.6

2024-12-260

PRE

Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus

多价mpox mRNA疫苗可引起强大的免疫反应，并对牛痘病毒提供有效的保护

IF6.9

2024-06-015

OA

Design, synthesis, and biological evaluation of novel 2'-methyl-2'-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2022-04-016

PRE

Organocatalytic Asymmetric Arylation of p-Quinone Phosphonates: A Green Access to Biaryl Monophosphorus Ligands

ORGANIC LETTERS

IF5

2021-09-229

PRE

The development of HEC-866 and its analogues for the treatment of idiopathic pulmonary fibrosis

RSC MEDICINAL CHEMISTRY

IF3.6

2021-01-012

OAAI

Design, Synthesis, and Resolution of Spirocyclic Bisoxindole-Based C2-Symmetric Diols

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2020-07-218

PREAI

Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase

CELL CHEMICAL BIOLOGY

IF7.2

2019-08-0117

OAAI

BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules

IF25.9

2019-06-1461

OAAI

CXCL13/CXCR5 signaling axis in cancer

CXCL13/CXCR5信号轴在癌症中的作用

IF5.1

2019-06-01116

PREAI

Development of an Efficient and Scalable Asymmetric Synthesis of Eliglustat via Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation

通过钌 (II) 催化的不对称转移氢化开发高效且可扩展的Eliglustat不对称合成

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2019-05-2318

PREAI

Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-11-0146

OAAI

3-((R)-4-(((R)-6-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic Acid (HEC72702), a Novel Hepatitis B Virus Capsid Inhibitor Based on Clinical Candidate GLS4

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-01-3027

PREAI

Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4)

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2017-02-0152

PRE

Synthesis and biological evaluation of novel dasatinib analogues as potent DDR1 and DDR2 kinase inhibitors

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2016-10-1724

PREAI

Skp1: Implications in cancer and SCF-oriented anti-cancer drug discovery

PHARMACOLOGICAL RESEARCH

IF10.5

2016-09-0128

PREAI

Implications of MDSCs-targeting in lung cancer chemo-immunotherapeutics

PHARMACOLOGICAL RESEARCH

IF10.5

2016-08-0122

PREAI

Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation

NATURE CHEMICAL BIOLOGY

IF13.7

2016-02-0194

OAAI

Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: A potential target for 'two-in-one' cancer chemoimmunotherapeutics

IF10.1

2015-12-0113

PREAI