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T

Theunis C. Goosen

University of North Carolina Chapel Hill

H指数:32

被引数:4,033

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Comparative Analysis of Isavuconazole DDIs With Other Azole Antifungal Drugs and PBPK Model-Informed Dosing Recommendations for Anticancer Drugs

伊曲康唑DDIs与其他唑类抗真菌药物的对比分析及基于PBPK模型的抗癌药物剂量推荐

CPT: Pharmacometrics & Systems Pharmacology

IF0

2025-10-170

OAAI

Development of a PBPK Model for Lamotrigine which Incorporates Metabolism by UGT2B10: Impact of UGT2B10 Poor Metabolizer Phenotype and Pregnancy

IF3.7

2025-02-040

PRE

UGT2B10 is the Major UDP-Glucuronosyltransferase 2B Isoform Involved in the Metabolism of Lamotrigine and is Implicated in the Drug-Drug Interaction with Valproic Acid

IF3.7

2024-09-251

PRE

Investigation of CYP3A induction by PF-05251749 in early clinical development: comparison of linear slope physiologically based pharmacokinetic prediction and biomarker response

CTS-CLINICAL AND TRANSLATIONAL SCIENCE

IF2.8

2022-07-025

OAAI

Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping

PHARMACOLOGY & THERAPEUTICS

IF12.5

2021-02-0141

PREAI

Physiologically-Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co-Administration with the UGT Inhibitor Mefenamic Acid

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2020-12-3014

OAAI

Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2018-05-0144

OAAI

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-09-1568

PREAI

Futatsugi, Kentaro; Kung, Daniel W.; Orr, Suvi T. M.; Cabral, Shawn; Hepworth, David; Aspnes, Gary; Bader, Scott; Bian, Jianwei; Boehm, Markus; Carpino, Philip A.; Coffey, Steven B.; Dowling, Matthew S.; Herr, Michael; Jiao, Wenhua; Lavergne, Sophie Y.; Li, Qifang; Clark, Ronald W.; Erion, Derek M.; Kou, Kou; Lee, Kyuha; Pabst, Brandon A.; Perez, Sylvie M.; Purkal, Julie; Jorgensen, Csilla C.; Goosen, Theunis C.; Gosset, James R.; Niosi, Mark; Pettersen, John C.; Pfefferkorn, Jeffrey A.; Ahn, Kay; Goodwin, Bryan

Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide

IF3.7

2014-05-1750

OA

Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and-2Bs in Human Liver Using NanoUPLC-MS/MS with Selected Reaction Monitoring

JOURNAL OF PROTEOME RESEARCH

IF3.6

2013-09-26125

PRE

Response to the Comment on the Article Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions

PHARMACEUTICAL RESEARCH

IF4.3

2013-03-063

PREAI

Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY

IF3.4

2013-01-2170

PREAI

Mechanistic Modeling to Predict the Transporter- and Enzyme-Mediated Drug-Drug Interactions of Repaglinide

PHARMACEUTICAL RESEARCH

IF4.3

2013-01-1094

PREAI

Insights into the Novel Hydrolytic Mechanism of a Diethyl 2-Phenyl-2-(2-arylacetoxy)methyl Malonate Ester-Based Microsomal Triglyceride Transfer Protein (MTP) Inhibitor

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2012-09-276

PREAI

Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions

PHARMACEUTICAL RESEARCH

IF4.3

2012-05-26131

PREAI

Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2007-08-1549

OAAI

Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2006-03-25104

PREAI

Bergamottin contribution to the grapefruit juice-felodipine interaction and disposition in humans

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2004-12-0192

OAAI

Percutaneous delivery of thalidomide and its N-alkyl analogs

PHARMACEUTICAL RESEARCH

IF4.3

2002-01-0112

OAAI

Physicochemical characterization and solubility analysis of thalidomide and its N-alkyl analogs

PHARMACEUTICAL RESEARCH

IF4.3

2002-01-0139

OAAI