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T

Tomáš Kučera

university of defence - czech republic
H指数:22
被引数:1,735

个人简介

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荣誉奖项

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Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-12-010
OAAI
Konecny, Jan; Misiachna, Anna; Chvojkova, Marketa; Kleteckova, Lenka; Kolcheva, Marharyta; Novak, Martin; Prchal, Lukas; Ladislav, Marek; Hemelikova, Katarina; Netolicky, Jakub; Hrabinova, Martina; Kobrlova, Tereza; Karasova, Jana Zdarova; Pejchal, Jaroslav; Fibigar, Jakub; Vecera, Zbynek; Kucera, Tomas; Jendelova, Pavla; Zahumenska, Petra; Langore, Emily; Doderovic, Jovana; Pang, Yuan-Ping; Vales, Karel; Korabecny, Jan; Soukup, Ondrej; Horak, Martin
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition

苯氧他克林衍生物: 低毒性神经保护剂，对ifenprodil结合位点和胆碱酯酶抑制具有亲和力

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-02-018
OAAI
Misiachna, Anna; Svobodova, Barbora; Netolicky, Jakub; Chvojkova, Marketa; Kleteckova, Lenka; Prchal, Lukas; Novak, Martin; Hrabinova, Martina; Kucera, Tomas; Muckova, Lubica; Moravcova, Zuzana; Karasova, Jana Zdarova; Pejchal, Jaroslav; Blazek, Filip; Malinak, David; Hakenova, Kristina; Krausova, Barbora Hrcka; Kolcheva, Marharyta; Ladislav, Marek; Korabecny, Jan; Pahnke, Jens; Vales, Karel; Horak, Martin; Soukup, Ondrej
2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1

2，6-二取代的7-(naphthalen-2-ylmethyl)-7h-嘌呤作为抑制DprE1的新型有效抗结核药

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2023-10-017
OAAI
Finger, Vladimir; Kucera, Tomas; Kafkova, Radka; Muckova, Lubica; Dolezal, Rafael; Kubes, Jan; Novak, Martin; Prchal, Lukas; Lakatos, Levente; Andrs, Martin; Hympanova, Michaela; Marek, Jan; Kufa, Martin; Spiwok, Vojtech; Soukup, Ondrej; Mezeiova, Eva; Janousek, Jiri; Nevosadova, Lenka; Benkova, Marketa; Kitson, Russell R. A.; Kratky, Martin; Bosze, Szilvia; Mikusova, Katarina; Hartkoorn, Ruben; Roh, Jaroslav; Korabecny, Jan
(±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease

(±)-BIGI-3h: 结合胆碱酯酶，单胺氧化酶和糖原合酶激酶3β 抑制作用的Pentatarget定向配体，具有钙通道拮抗作用和抗聚集特性，可用于阿尔茨海默氏病

ACS CHEMICAL NEUROSCIENCE
IF3.9
2021-04-0229
PREAI
Ismaili, Lhassane; Monnin, Julie; Etievant, Adeline; Arribas, Raquel L.; Viejo, Lucia; Refouvelet, Bernard; Soukup, Ondrej; Janockova, Jana; Hepnarova, Vendula; Korabecny, Jan; Kucera, Tomas; Jun, Daniel; Andrys, Rudolf; Musilek, Kamil; Baguet, Aurelie; Garcia-Frutos, Eva M.; De Simone, Angela; Andrisano, Vincenza; Bartolini, Manuela; de Los Rios, Cristobal; Marco-Contelles, Jose; Haffen, Emmanuel
Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-03-2216
OAAI
Jirkovska, Anna; Karabanovich, Galina; Kubes, Jan; Skalicka, Veronika; Melnikova, Iuliia; Korabecny, Jan; Kucera, Tomas; Jirkovsky, Eduard; Novakova, Lucie; Piskackova, Hana Bavlovic; Skoda, Josef; Sterba, Martin; Austin, Caroline A.; Simunek, Tomas; Roh, Jaroslav
Substituted Piperazines as Novel Potential Radioprotective Agents

取代哌嗪作为新型潜在的辐射防护剂

MOLECULES
IF4.6
2020-01-258
OAAI
Filipova, Alzbeta; Marek, Jan; Havelek, Radim; Pejchal, Jaroslav; Jelicova, Marcela; Cizkova, Jana; Majorosova, Martina; Muckova, Lubica; Kucera, Tomas; Prchal, Lukas; Psotka, Miroslav; Zivna, Natalie; Koutova, Darja; Sinkorova, Zuzana; Rezacova, Martina; Tichy, Ales
Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors

针对冈比亚乙酰胆碱酯酶的半胱氨酸靶向杀虫剂既不是选择性的也不是可逆的抑制剂

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2019-11-2613
OAAI
Gorecki, Lukas; Andrys, Rudolf; Schmidt, Monika; Kucera, Tomas; Psotka, Miroslav; Svobodova, Barbora; Hrabcova, Veronika; Hepnarova, Vendula; Bzonek, Petr; Jun, Daniel; Kuca, Kamil; Korabecny, Jan; Musilek, Kamil

研究方向

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J
Jan Korábečný
H 指数:43论文数:270被引数:6,148
O
Ondřej Soukup
H 指数:41论文数:250被引数:5,505
D
Daniel Jun
H 指数:47论文数:419被引数:8,776
Ľ
Ľubica Múčková
H 指数:16论文数:68被引数:978
M
Martina Hrabinová
H 指数:29论文数:135被引数:2,471
L
Lukáš Prchal
H 指数:16论文数:98被引数:915
R
Rafael Doležal
H 指数:27论文数:130被引数:2,283
K
Kamil Kuča
H 指数:92论文数:1,357被引数:4.5万
V
Vendula Hepnarová
H 指数:15论文数:55被引数:634
J
Jaroslav Pejchal
H 指数:24论文数:157被引数:1,763