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C

Cornelis E. C. A. Hop

genentech, inc.

H指数:48

被引数:7,107

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Total drug’s last stand on phospholipidosis: Unbound drug rules!

总药物在磷脂质症中的最后阵地：游离药物占主导地位！

Drug Metabolism and Disposition

IF4

2025-11-070

PRE

Beyond Single-Dose Human Mass Balance Study: Minimizing Subject Confinement and Enabling True Steady State Assessment with a Novel Multiple-Dose Design Proposal

超越单剂量人体总平衡研究：通过一种新型多剂量设计方案，减少受试者隔离并实现真正的稳态评估

Drug Metabolism and Disposition

IF4

2025-09-260

PRE

Elucidating Molecular Mechanisms of Drug-Induced Hepatotoxicity of Lapatinib

阐明拉帕替尼药物诱导肝毒性的分子机制

Journal of Medicinal Chemistry

IF6.8

2025-07-250

PRE

Transporter expressions as part of required scaling factor to support in vitro in vivo extrapolation for blood-brain barrier drug permeability

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2025-01-010

OA

Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs

COMMUNICATIONS MEDICINE

IF6.3

2024-05-163

OA

Introducing the Dynamic Well-Stirred Model for Predicting Hepatic Clearance and Extraction Ratio

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2024-04-015

OAAI

Artificial Intelligence for Quantitative Modeling in Drug Discovery and Development: An Innovation and Quality Consortium Perspective on Use Cases and Best Practices

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2023-10-0619

OAAI

New Methodology for Determining Plasma Protein Binding Kinetics Using an Enzyme Reporter Assay Coupling with High-Resolution Mass Spectrometry

ANALYTICAL CHEMISTRY

IF6.7

2023-02-1510

PRE

Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs (vol 64, pg 7045, 2021)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-10-210

OA

Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-05-1911

OAAI

Strategy for Determining the Free Fraction of Labile Covalent Modulators in Plasma Using Equilibrium Dialysis

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2020-10-0112

PREAI

Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2019-07-2683

OAAI

Positron Emission Tomography Imaging of [11C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2019-07-2251

OAAI

Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational Pharmacokinetic-Pharmacodynamic Analysiss

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2019-06-017

OAAI

Opportunities and challenges using artificial intelligence in ADME/Tox

NATURE MATERIALS

IF38.5

2019-04-1864

OAAI

Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood-Brain Barrier Measured by Quantitative Targeted Proteomics

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2019-03-1865

PREAI

Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bidirectional Equilibrium Dialysis

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2019-03-0126

PREAI

Strategies to optimize drug half-life in lead candidate identification

EXPERT OPINION ON DRUG DISCOVERY

IF4.9

2019-01-2412

PREAI

Strategies of Drug Transporter Quantitation by LC-MS: Importance of Peptide Selection and Digestion Efficiency (vol 19, pg 1469, 2017)

IF3.7

2018-06-061

OAAI

Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates

MOLECULAR CANCER THERAPEUTICS

IF5.5

2018-02-2832

OAAI