Neil Parrott - Publications, H-index & Citations

Neil Parrott

roche holding

46H指数

214论文数

7.1K被引数

收录论文 45

发表时间

PQRI Workshop: Model-Informed Drug Development (MIDD) Approaches in Pediatric Formulation Development PQRI研讨会：儿科制剂开发中的模型引导药物开发（MIDD）方法

The AAPS Journal

IF0

2026-03-09

OAAI

Gilbert J. Burckart; Susan Abdel-Rahman; Caleb Choi; M. Petrea Cober; James E. Cummins; Nikoletta Fotaki; Daniel Gonzalez; David Harris; Neil Parrott; Hardikkumar Patel; Fang Wu; Andreas Abend

Combining the novel all-human co-cultured hepatocytes system with physiologically based pharmacokinetic modeling to assess the translatability of cytochrome P450 and uridine 5 ′ -diphospho-glucuronosyltransferase induction data 结合新型全人共培养肝细胞系统与生理药代动力学模型评估细胞色素P450和尿苷5′-二磷酸葡糖基转移酶诱导数据的可转化性

Drug Metabolism and Disposition

IF4

2026-03-01

OAAI

Pugliano, Alessandra; Ekiciler, Aynur; Parrott, Neil John; Annaert, Pieter; Preiss, Lena; Umehara, Kenichi

Fraction metabolized by cytochrome P450 enzymes: A comprehensive evaluation of the translatability of an in vitro HepatoPac assay

Drug Metabolism and Disposition

IF4

2026-01-15

PREAI

Florian Klammers; Thanusa Shanmugalingam; Tobias Remus; Alexander Schriewer; Isabelle Walter; Neil Parrott; Kenichi Umehara

Future Directions in Drug-Drug Interaction Evaluations: Industry Perspective on the ICH M12 Guidance 药物相互作用评价的未来方向：行业对ICH M12指导原则的视角

Drug Metabolism and Pharmacokinetics

IF2.2

2025-12-12

PREAI

Kenichi Umehara; Andrew Harrell; Chandra Prakash; Constanze Hilgendorf; T.Eric Ballard; Felix Huth; Justine Badée; Licong Jiang; Manoli Vourvahis; Natasa Pajkovic; Neil Parrott; Nilay Thakkar; Patrik Marroum; Ronald Laethem; Shiyao Xu; Yuan Chen

Current Status of Prediction of IL-6 Mediated Cytochrome P450 Activity Modulation using In Vitro Data and PBPK Modeling IL-6介导的细胞色素P450活性调节的预测现状：基于体外数据和PBPK建模

Drug Metabolism and Pharmacokinetics

IF2.2

2025-12-09

PREAI

Viktor Georgiev; Isabelle Anderka; Delia Bucher; Lena Preiss; Jitao David Zhang; Kenichi Umehara; Neil Parrott

Physiologically-Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges 基于生理学的药代动力学建模以支持儿科临床开发：IQ工作组关于当前状况和挑战的观点

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2025-11-01

OAAI

Yates, James W. T.; Zientek, Michael; Taskar, Kunal S.; Lin, Wen; Heimbach, Tycho; Willmann, Stefan; Rehmel, Jessica; Parrott, Neil; Hanley, Michael; Badee, Justine; Chen, Yuan; Cole, Susan; De Zwart, Loeckie; Haertter, Sebastian; Jiang, Rongrong; Kotsuma, Masakatsu; Liang, Guiqing; Lin, Yu-Wei; Liu, Jing; Ou, Ying; Rascher, Juliane; Shaik, Naveed A.; Wahlstrom, Jan; Wang, Xiaofeng; Xiao, Guangqing; Yee, Ka Lai; Cheung, S. Y. Amy

Optimization of In Vitro CYP3A4 TDI Assay Conditions and Use of Derived Parameters for Clinical DDI Risk Assessment Using Static and Dynamic Models 体外CYP3A4 TDI试验条件的优化及利用导出参数结合静态和动态模型进行临床DDI风险评估

aaps journal

IF0

2025-08-13

OAAI

Alessandra Pugliano; Aynur Ekiciler; Lena Preiss; Neil John Parrott; Pieter Annaert; Kenichi Umehara

Prospective DDI Risk Assessment of Vicasinabin with PBPK Modeling by Integrating In Vitro Data 基于整合体外数据的Vicasinabin与PBPK建模的前瞻性DDI风险评价

Clinical Pharmacology & Therapeutics

IF5.5

2025-04-28

PREAI

Kenichi Umehara; Neil Parrott; Andreas Günther; Katrijn Bogman

Investigating the effect of whey and casein proteins on drug solubility from a paediatric drug absorption perspective

international journal of pharmaceutics

IF6.4

2024-12-01

OAAI

Van der Veken, Matthias; Brouwers, Joachim; Parrott, Neil; Augustijns, Patrick; Stillhart, Cordula

Building Confidence in Physiologically Based Pharmacokinetic Modeling of CYP3A Induction Mediated by Rifampin: An Industry Perspective

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2024-10-18

OAAI

Reddy, Micaela B.; Cabalu, Tamara D.; de Zwart, Loeckie; Ramsden, Diane; Dowty, Martin E.; Taskar, Kunal S.; Badee, Justine; Bolleddula, Jayaprakasam; Boulu, Laurent; Fu, Qiang; Kotsuma, Masakatsu; Leblanc, Alix F.; Lewis, Gareth; Liang, Guiqing; Parrott, Neil; Pilla Reddy, Venkatesh; Prakash, Chandra; Shah, Kushal; Umehara, Kenichi; Mukherjee, Dwaipayan; Rehmel, Jessica; Hariparsad, Niresh

Oral Absorption from Surfactant-Based Drug Formulations: The Impact of Molecularly Dissolved Drug on Bioavailability

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2024-10-01

OAAI

Holzem, Florentin Lukas; Parrott, Neil; Schaffland, Jeannine Petrig; Brandl, Martin; Bauer-Brandl, Annette; Stillhart, Cordula

PBPK Modeling of Entrectinib and Its Active Metabolite to Derive Dose Adjustments in Pediatric Populations Co-Administered with CYP3A4 Inhibitors

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2024-07-18

PREAI

Umehara, Kenichi; Parrott, Neil; Schindler, Emilie; Legras, Valentin; Meneses-Lorente, Georgina

Another string to your bow: machine learning prediction of the pharmacokinetic properties of small molecules

EXPERT OPINION ON DRUG DISCOVERY

IF4.9

2024-05-10

OAAI

Bassani, Davide; Parrott, Neil John; Manevski, Nenad; Zhang, Jitao David

Mechanistic Modeling of In Vitro Biopharmaceutic Data for a Weak Acid Drug: A Pathway Towards Deriving Fundamental Parameters for Physiologically Based Biopharmaceutic Modeling

AAPS JOURNAL

IF3.7

2024-04-04

PREAI

Kowthavarapu, Venkata Krishna; Charbe, Nitin Bharat; Gupta, Churni; Iakovleva, Tatiana; Stillhart, Cordula; Parrott, Neil John; Schmidt, Stephan; Cristofoletti, Rodrigo

In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2024-02-14

OAAI

Milani, Nicolo; Parrott, Neil; Galetin, Aleksandra; Fowler, Stephen; Gertz, Michael

Development and application of neonatal physiology-based pharmacokinetic models of amikacin and fosfomycin to assess pharmacodynamic target attainment

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2024-01-03

OAAI

Darlow, Christopher A.; Parrott, Neil; Peck, Richard W.; Hope, William

Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL-6 levels following administration of the T-cell bispecific engager glofitamab

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2023-12-14

OAAI

Djebli, Nassim; Parrott, Neil; Jaminion, Felix; O'Jeanson, Amaury; Guerini, Elena; Carlile, David

Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study. ( vol 14, 1935, 2022)

PHARMACEUTICS

IF5.5

2023-09-15

OAAI

van der Veken, Matthias; Aertsen, Michael; Brouwers, Joachim; Stillhart, Cordula; Parrott, Neil; Augustijns, Patrick

Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding

PHARMACEUTICS

IF5.5

2023-08-29

OAAI

van der Veken, Matthias; Brouwers, Joachim; Ozbey, Agustos Cetin; Umehara, Kenichi; Stillhart, Cordula; Knops, Noel; Augustijns, Patrick; Parrott, Neil John

Streamlining Food Effect Assessment - Are Repeated Food Effect Studies Needed? An IQ Analysis

AAPS JOURNAL

IF3.7

2023-06-15

PREAI

Kesisoglou, Filippos; Basu, Sumit; Belubbi, Tejashree; Bransford, Philip; Chung, John; Dodd, Stephanie; Dolton, Michael; Heimbach, Tycho; Kulkarni, Priyanka; Lin, Wen; Moir, Andrea; Parrott, Neil; Pepin, Xavier; Ren, Xiaojun; Sharma, Pradeep; Stamatopoulos, Konstantinos; Tistaert, Christophe; Vaidhyanathan, Shruthi; Wagner, Christian; Riedmaier, Arian Emami

研究方向