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Lei Shi

national institutes of health

59H指数
328论文数
1.4W被引数
收录论文 166
发表时间
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Coordinated Subpocket Engagement Underlies Nitazene Potency at the μ-Opioid Receptor协同亚口袋结合是氮杂吲哚类阿片类药物在μ-阿片受体上发挥作用的基础
errACS Chemical Neuroscience
IF3.9
err2026-07-05
err0
PREAI
errMargaret Jane Robinson; Li Chen; Abhishek Thakur; Kuo-Hao Lee; Lei Shi
err分享
err收藏
Distinct pharmacological profile of a dopamine D3 receptor ligand with potential therapeutic effect in restless legs syndrome具有潜在治疗作用的 dopamine D3 受体配体在不安腿综合征中的独特药理特性
errSleep
IF4.9
err2026-05-15
err0
PREAI
errYuan-Yang Lai; Bradley M Keegan; Marc Ciruela-Jardí; Jian Jing Cao; Kung-Chiao Hsieh; Christopher J Earley; Lei Shi; Estefanía Moreno; Leonardo Pardo; Amy H Newman; Jerome M Siegel; Sergi Ferré
err分享
err收藏
A µ-opioid receptor superagonist analgesic with minimal adverse effects一种具有最小不良反应的μ-阿片受体超激动剂镇痛药
errNature
IF48.5
err2026-04-01
err0
errOAAI
errJuan L. Gomez; Emilya N. Ventriglia; Zachary J. Frangos; Agnieszka Sulima; Michael J. Robertson; Michael D. Sacco; Reece C. Budinich; Ilinca M. Giosan; Tongzhen Xie; Oscar Solis; Anna E. Tischer; Jennifer M. Bossert; Kiera E. Caldwell; Hannah Bonbrest; Amelie Essmann; Zelai M. Garçon-Poca; Shinbe Choi; Michael R. Noya; Feonil Limiac; Ali Arce; Grant C. Glatfelter; Margaret Robinson; Li Chen; Angelina A. Mullarkey; Dain R. Brademan; Garrett Enten; William Dunne; César Quiroz; Ingrid Schoenborn; Chae Bin Lee; Rana Rais; Daniel P. Holt; Robert F. Dannals; Lei Shi; Ruth Hüttenhain; Sergi Ferré; Eugene Kiyatkin; Jordi Bonaventura; Yavin Shaham; Venetia Zachariou; Michael H. Baumann; Georgios Skiniotis; Kenner C. Rice; Michael Michaelides
err分享
err收藏
Structure–Function Activity Relationships of Cariprazine Analogues with Distinct G Protein versus β-Arrestin Activities at the Dopamine D3 Receptor卡立普新类似物的结构-功能活性关系：在多巴胺D3受体上具有不同G蛋白与β-阿restin活性的研究
errACS Chemical Neuroscience
IF3.9
err2025-11-28
err0
PREAI
errBradley M. Keegan; Caleb D. Vogt; Li Chen; Renee J. Nosko; Elizabeth Saab; Alessandro Bonifazi; Emma S. Gogarnoiu; Anver Basha Shaik; Amy Hauck Newman; Lei Shi
err分享
err收藏
Nightmare frequency mediates the association between childhood trauma and suicidal ideation among youth: is it sex-specific?噩梦频率调节童年创伤与青少年自杀意念之间的关联：这种调节作用是否具有性别特异性？
errEuropean Archives of Psychiatry and Clinical Neuroscience
IF3.7
err2025-11-17
err0
errOAAI
errJianyu Que; Yan’e Lu; Jingrou Liu; Lei Shi; Suying Wu; Ciping You; Xiao Chen; Duoduo Lin; Farong Liu; Jia Jia Liu
err分享
err收藏
Pharmacokinetic-pharmacodynamic target attainment analyses as support for meropenem dosing regimens in critically ill adult and elderly patients with Pseudomonas aeruginosa infections美罗培南在危重成年及老年患者铜绿假单胞菌感染中的给药方案，其药代动力学-药效学目标达成分析作为支持依据。
errFrontiers in Pharmacology
IF4.8
err2025-09-26
err0
errOAAI
errRuyu Tao†; Sumyeut Chan†; Jinxingyi Wang†; Xianhe Wang; Lei Shi; Xue Lan; Ling Chen; Xiaohui Mu
err分享
err收藏
Discovery; Characterization; and Optimization of a Novel Positive Allosteric Modulator-Antagonist of the D3 Dopamine Receptor发现、表征和优化一种新型的D3多巴胺受体阳性别构调节剂-拮抗剂
errJournal of Medicinal Chemistry
IF6.8
err2025-08-01
err0
PREAI
errAmy E. Moritz; Feijun Wang; Nora S. Madaras; Amber M. Kelley; Kirsten K. Snyder; Disha Gandhi; Laura R. Inbody; Emmanuel O. Akano; Lei Shi; J. Robert Lane; R. Benjamin Free; Kevin J. Frankowski; David R. Sibley
err分享
err收藏
Locomotor activity depends on β-arrestin recruitment by the dopamine D1 receptor in the striatal D1-D3 receptor heteromer运动活动依赖于纹状体D1-D3受体异聚体中多巴胺D1受体对β-抑制蛋白的募集。
errPharmacological Research
IF10.5
err2025-06-14
err0
errOAAI
errAlexandra H. Evans; Marc Ciruela-Jardí; William Rea; Bradley M. Keegan; Marjorie R. Levinstein; Alessandro Bonifazi; Jianjing Cao; Shelley N. Jackson; Lei Shi; Nil Casajuana-Martin; Ning-Sheng Cai; Vicent Casadó; Christopher J. Earley; Amy H. Newman; Michael Michaelides; Leonardo Pardo; Estefanía Moreno; Sergi Ferré
err分享
err收藏
Preclinical Pharmacology of N-Pyrrolidino Nitazene Opioids (P-Nitazenes) Emerging in Clandestine Drug MarketsN-吡咯啶异阿尼亭类阿片类药物（P-异阿尼亭）的上市前药理学研究——该类物质在秘密毒品市场中的出现
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errBaumann, Michael H.; Maitland, Alexander D.; Walther, Donna; Chen, Li; Shi, Lei; Glatfelter, Grant C.
err分享
err收藏
N-terminal fragment shedding contributes to signaling of the full-length adhesion receptor ADGRL3N端片段脱落有助于全长粘附受体ADGRL3的信号传导
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-02-01
err0
PREAI
errPerry-Hauser, Nicole A.; Du Rand, Jonathan R.; Lee, Kuo Hao; Shi, Lei; Javitch, Jonathan A.
err分享
err收藏
Ligand Reorganization for End-Point Binding Free Energy Calculations: Identifying Preferred Poses of Fentanyls in the μ Opioid Receptor用于终点结合自由能计算的配体重组: 确定 μ 阿片受体中芬太尼的首选姿势
errJOURNAL OF CHEMICAL THEORY AND COMPUTATION
IF5.5
err2025-01-13
err0
PREAI
errMinh, David D. L.; Cooper, David A.; Xie, Bing; Shi, Lei
err分享
err收藏
FOXCUT regulates the malignant phenotype of triple-negative breast Cancer via the miR-337-3p/ANP32E AxisFOXCUT通过miR-337-3p/ANP32E轴调节三阴性乳腺癌的恶性表型
errGENOMICS
IF3
err2024-09-01
err0
errOAAI
errShi, Lei; Zhang, Ziwen; Huang, Yuan; Zheng, Yabing
err分享
err收藏
PHARMACOLOGICAL EFFECTS OF 2-BENZYLBENZIMIDAZOLE OPIOIDS EMERGING IN CLANDESTINE DRUG MARKETS WORLDWIDE
errDRUG AND ALCOHOL DEPENDENCE
IF3.6
err2024-07-01
err0
PREAI
errBaumann, Michael; Walther, Donna; Tsai, Meng-Hua; Chen, Li; Vandeputte, Marthe; Stove, Christophe; Shi, Lei; Glatfelter, Grant
err分享
err收藏
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism
errCELL DEATH DISCOVERY
IF7
err2024-04-22
err2
errOAAI
errWang, Jianwei; Yin, Hongli; Li, Gen; Wu, Di; Xu, Yunyun; Chen, Yanling; Wang, Xiaodong; Xing, Yujiao; Zhang, Ting; Fei, Danhong; Yang, Pengcheng; Fang, Fang; Tao, Yanfang; Li, Xiaolu; Yu, Juanjuan; Yang, Yang; Li, Zhiheng; Shi, Lei; Zhang, Zimu; Pan, Jian
err分享
err收藏
Unraveling Activation-Related Rearrangements and Intrinsic Divergence from Ligand-Specific Conformational Changes of the Dopamine D3 and D2 Receptors
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-03-08
err0
PREAI
errLee, Kuo Hao; Shi, Lei
err分享
err收藏
In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-02-12
err5
PREAI
errTsai, Meng-Hua M.; Chen, Li; Baumann, Michael H.; Canals, Meritxell; Javitch, Jonathan A.; Lane, J. Robert; Shi, Lei
err分享
err收藏
Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2024-01-09
err0
errOAAI
errCouly, Simon; Yasui, Yuko; Foncham, Semnyonga; Grammatikakis, Ioannis; Lal, Ashish; Shi, Lei; Su, Tsung-Ping
err分享
err收藏
Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-12-20
err3
PREAI
errOkorom, Amarachi V.; Camacho-Hernandez, Gisela Andrea; Salomon, Kristine; Lee, Kuo Hao; Ku, Therese C.; Cao, Jianjing; Won, Sung Joon; Friedman, Jacob; Lam, Jenny; Paule, James; Rais, Rana; Klein, Benjamin; Xi, Zheng-Xiong; Shi, Lei; Loland, Claus J.; Newman, Amy Hauck
err分享
err收藏
Subtle Structural Modification of a Synthetic Cannabinoid Receptor Agonist Drastically Increases its Efficacy at the CB1 Receptor
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2023-10-17
err3
errOAAI
errYano, Hideaki; Chitsazi, Rezvan; Lucaj, Christopher; Tran, Phuong; Hoffman, Alexander F.; Baumann, Michael H.; Lupica, Carl R.; Shi, Lei
err分享
err收藏
Dynamic extracellular vestibule of human SEPT: Unveiling druggable potential with high- affinity allosteric inhibitors
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-10-04
err3
errOAAI
errSalomon, Kristine; Abramyan, Ara M.; Plenge, Per; Wang, Lingle; Bundgaard, Christoffer; Bang-Andersen, Benny; Loland, Claus J.; Shi, Lei
err分享
err收藏

研究方向

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合作学者
合作期刊
P
Peter B. Jones
H 指数: 139 · 论文数: 1.6K
C
Carl Nathan
H 指数: 127 · 论文数: 425
C
C.H. Arrowsmith
H 指数: 112 · 论文数: 3.1K
Y
Yavin Shaham
H 指数: 109 · 论文数: 2.2K
M
Martin G. Pomper
H 指数: 101 · 论文数: 1.0K
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