Wagdy M. Eldehna - Publications, H-index & Citations

Wagdy M. Eldehna

Kafrelsheikh University

56H指数

309论文数

9.0K被引数

收录论文 199

发表时间

Mutant isocitrate dehydrogenase in cancer: Structural biology, small-molecule inhibitors, and future drug discovery strategies 癌症中的突变异柠檬酸脱氢酶：结构生物学、小分子抑制剂及未来药物发现策略

Drug Discovery Today

IF7.5

2026-09-06

PREAI

Moataz A. Shaldam; Anwar A. El-Hamaky; Nourhan A. Khattab; Salma M. Hefny; Mohamed S. Nafie; Wagdy M. Eldehna; Haytham O. Tawfik

Pyrazoline- and Hydrazone-Linked Thiazole-Triazole Hybrids as Potent Dual-Stage Antileishmanial Agents with Antifolate Activity 吡唑并-和肼基-连接的噻唑-三唑杂合物作为具有抗叶酸活性的强效双阶段抗利什曼原虫剂

European Journal of Medicinal Chemistry Reports

IF4.1

2026-09-01

OAAI

Esraa A. Abdelsalam; Wagdy M. Eldehna; Sherif F. Hammad; Nicolas Masurier; Tamer M. Ibrahim; Kikuko Amagase; Sherry N. Nasralla; Yara E. Mansour; Hatem A. Abdel-Aziz; Adnan A. Bekhit; Radwan El-Haggar

Striking two targets with one scaffold via benzo[d]imidazole-isatin conjugates as potent dual VEGFR-2/c-MET antagonists 通过苯并[d]咪唑-异吲哚酮偶联物作为强效双重VEGFR-2/c-MET拮抗剂，实现一 Scaffold 拓扑双靶点精准打击

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2026-08-26

PREAI

Mohamed El-Naggar; Rofaida Salem; Mona M. Kabeel; Ihsan A. Shehadi; Wagdy M. Eldehna; Hatem A. Abdel-Aziz; Mahmoud S. Elkotamy

Targeting CDK-2 With Novel Indole-Pyrazole Hybrids: Discovery of Potent Anticancer Agents Supported by Mechanistic and In Silico Studies 靶向CDK-2的新型吲哚-吡唑杂合体：基于机制和计算机模拟研究的强效抗癌剂发现

Drug Development Research

IF4.2

2026-08-19

PREAI

Wagdy M. Eldehna; Zainab M. Elsayed; Mohamed R. Elnagar; Yasser M. Omar; Maha-Hamadien Abdulla; Abdulrahman M. Saleh; Abdelrahman R. Shalabi; Diaaeldin M. Elimam; Suliman Alshamari; Mohamed Fares; Haytham O. Tawfik

Molecular Boomerangs Against Cancer: Design, Synthesis, Biological Evaluation, and In Silico Study of Novel Dual PARP-1/EGFR Inhibitors 抗癌症的分子回旋镖：新型双PARP-1/EGFR抑制剂的分子设计、合成、生物评价及计算机模拟研究

Drug Development Research

IF4.2

2026-05-28

PREAI

Haytham O. Tawfik; Amr Tayel; Salma M. Hefny; Tarfah Al-Warhi; Nada K. Sedky; Anwar A. El-Hamaky; Nourhan A. Khattab; Ahmed K. B. A. W. Farouk; Moataz A. Shaldam; Wagdy M. Eldehna; Mohamed S. Nafie

Design and Synthesis of Indole-Based Imidazo[1; 2-a]pyridine Derivatives as Antiseizure Candidates: Evaluation in Chemically Induced Seizure Models and In Vitro Antioxidant Assays 基于吲哚的咪唑并[1,2-a]吡啶衍生物作为抗惊厥候选药物的设计与合成：在化学诱导惊厥模型和体外抗氧化实验中的评估

ACS Chemical Neuroscience

IF3.9

2026-05-15

PREAI

Tarfah Al-Warhi; Mahmoud S. Elkotamy; Mahmoud Abdelrahman Alkabbani; Zainab M. Elsayed; Mohamed D. Morsy; Mostafa M. Elbadawi; Wagdy M. Eldehna

The Effect of Arylquinoline-Based EGFR and FAK Kinase Inhibitors on the Activity of Major Cytochrome P450 Enzymes 芳基喹啉类EGFR和FAK激酶抑制剂对主要细胞色素P450酶活性的影响

European Journal of Drug Metabolism and Pharmacokinetics

IF2.4

2026-05-01

PREAI

Elbarbry, Fawzy; Espiritu, Michael; Hecker, Bethany; Elbadawi, Mostafa M.; Eldehna, Wagdy M.

Discovery of a Mixed and Prodrug-Like Inhibition Mechanism for Phosphocoumarins and Phosphoquinolinones against Human Carbonic Anhydrases 发现磷香豆素和磷喹啉酮对人碳酸酐酶的混合型和前药样抑制机制

Journal of Medicinal Chemistry

IF6.8

2026-04-29

OAAI

Alessio Nocentini; Simone Giovannuzzi; Vincenzo Alterio; Alessandro Bonardi; Rudolfs Barons; Raivis Zalubovskis; Wagdy M. Eldehna; Rossella Aronne; Davide Esposito; Enrico Luchinat; Giuseppina De Simone; Gianluca Bartolucci; Paola Gratteri; Mattia Mori; Claudiu T. Supuran

Pyrazole–triazole hybrids as kinase-triad inhibitors: a triple-target strategy for synergistic anticancer therapy 吡唑-三唑杂化物作为激酶-三联抑制剂：协同抗癌疗法的三重靶点策略

rsc med. chem.

IF0

2026-04-22

PREAI

Mahmoud S. Elkotamy; Mohamed K. Elgohary; Mariam M. Fakhry; Mohamed E. Albakri; Abdelrahman A. Naglah; Abdulrahman A. Almehizia; Ahmed M. Naglah; Mohamed Fares; Haytham O. Tawfik; Wagdy M. Eldehna; Hatem A. Abdel-Aziz

Click chemistry synthesis of triazole-grafted quinazolinones as new multi-panel anticancer agents: mechanistic insights into apoptosis and cell cycle arrest in colorectal cancer 三唑基喹唑啉酮的点击化学合成及其作为新型多靶点抗癌药物的应用：对结直肠癌中凋亡机制和细胞周期阻滞的机制洞察

Bioorganic Chemistry

IF4.7

2026-04-07

PREAI

Mohammad M. Al-Sanea; Mohamed R. Elnagar; Hamed W. El-Shafey; Marwa I. Serag; Nimah Saad Alanzi; Mahmoud S. Elkotamy; Rofaida Salem; Wagdy M. Eldehna; Abdelrahman Hamdi

Multi-target pyrazolopyrimidine-coumarin derivatives as potent CA IX/XII and tubulin polymerization inhibitors: Design, synthesis, and biological evaluation 多靶点吡唑嘧啶-香豆素衍生物作为CA IX/XII和微管蛋白聚合的强效抑制剂：设计、合成及生物评价

European Journal of Medicinal Chemistry

IF5.9

2026-03-20

PREAI

Mahmoud S. Elkotamy; Mohamed A. Abdelrahman; Simone Giovannuzzi; Mahmoud Abdelrahman Alkabbani; Alessio Nocentini; Claudiu T. Supuran; Wagdy M. Eldehna; Hatem A. Abdel-Aziz; Sahar M. Abou-Seri

Biphenyl urea derivatives as novel GPX4 inhibitors: ferroptosis-mediated antiproliferative activity against CNS cancer cells 联苯脲衍生物作为新型GPX4抑制剂：介导铁死亡的抗增殖活性针对CNS癌细胞

Bioorganic Chemistry

IF4.7

2026-03-05

PREAI

Wagdy M. Eldehna; Salma M. Hefny; Heba A. Elsebaie; Heba Aref; Anwar A. El-Hamaky; Haytham O. Tawfik; Moataz A. Shaldam

Isatin-triazole/imidazole hybrids as dual CDK2/VEGFR2 inhibitors with potent anti-cancer activity: design, synthesis, and biological evaluations

Bioorganic Chemistry

IF4.7

2026-03-01

PREAI

Elsayed, Zainab M.; Balaha, Marwa; Tawfik, Haytham O.; Khaleel, Eman F.; Shaldam, Moataz A.; Negmeldin, Ahmed T.; Al-Ansary, Ghada H.; Elimam, Diaaeldin M.; Omar, Yasser M.; di Giacomo, Viviana; Eldehna, Wagdy M.

N-(Benzofuran-3-ylmethyl)isatin derivatives as potential SARS-CoV-2 main protease inhibitors: Synthesis, biological evaluation, kinetic analysis, and molecular modeling insights N-(苯并呋喃-3-基甲基)吲哚酮衍生物作为潜在SARS-CoV-2主要蛋白酶抑制剂：合成、生物评价、动力学分析和分子建模见解

Journal of Molecular Structure

IF4.7

2026-02-16

PREAI

Wagdy M. Eldehna; Md Sofequl Islam Mukim; Mohamed M. Eldesouki; Mahmoud A․El Hassab; Rehan Monir; Mohamed M. Hefina; Shimaa M. Hamed; Mostafa M. Elbadawi; Mohamed Elagawany; Ashraf K. El-Damasy; Dae-Geun Song; Hatem A. Abdel-Aziz

First-in-Class Dual PDGFR/Carbonic Anhydrase IX/XII Inhibitors: 6; 7-Dimethoxyquinoline-Sulfonamides as Promising Antileukemic Agents 一流的双重PDGFR/碳酸酐酶IX/XII抑制剂: 6; 7-二甲氧基喹啉-磺酰胺作为有前途的抗白血病药

Journal of Medicinal Chemistry

IF6.8

2026-01-26

OAAI

Eslam Roshdy; Eva Řezníčková; Mostafa M. Elbadawi; Ismail Celik; Simone Giovannuzzi; Denisa Veselá; Veronika Vojáčková; Petra Krňávková; Alessio Nocentini; Claudiu T. Supuran; Vladimír Kryštof; Wagdy M. Eldehna; Manabu Abe

Synthesis of New trans-Ferulic Acid Derivatives as Potential Anticancer Agents and VEGFR-2 Inhibitors

rsc med. chem.

IF0

2026-01-24

PREAI

Asmaa N Mohie; Mahmoud A Doheim; Ragab A El Masry; Ayman M El-Sayed; Rofaida Salem; Haytham O. Tawfik; Wagdy M. Eldehna

Synthesis and Biological Evaluation of Imidazopyridine-Isatin Hybrids as Inhibitors of Leishmania major Growth 咪唑吡啶-异吲哚酮杂合物的合成及其对利什曼原虫主要株生长抑制的生物评价

Drug Design Development and Therapy

IF5.1

2026-01-01

PREAI

El Hassab, Mahmoud A.; Eldehna, Wagdy M.; Elsayed, Zainab M.; Elbadawi, Mostafa M.; Negmeldin, Ahmed T.; Balaha, Marwa; Nasralla, Sherry N.; Monir, Rehan; Ibrahim, Tamer M.; Abe, Manabu; Tawfik, Haytham O.; Bekhit, Adnan A.; Hemeda, Loah R.

Discovery of Enaminone-Linked Benzofuran Derivatives as Dual VEGFR-2/hCA IX Inhibitors Exhibiting Hypoxia-Mediated Chemosensitization 作为具有缺氧介导的化学增敏作用的二重VEGFR-2/hCA IX抑制剂的Enaminone连接的苯并呋喃衍生物的发现

RSC Med. Chem.

IF0

2025-12-18

PREAI

Wagdy M. Eldehna; Zainab Elsayed; Mohamed Elnagar; Andrea Ammara; Mahmoud S Elkotamy; Rehan Monir; Alessio Nocentini; Mohammad M. Al-Sanea; Claudiu Supuran; Haytham O. Tawfik; Hatem A. Abdel-Aziz; Ahmed T. Negmeldin

Rational Design of Triazole Hydrazide Derivatives With Imidazo[2,1-b]thiazole Scaffolds as Targeted EGFR Inhibitors in NSCLC

DRUG DEVELOPMENT RESEARCH

IF4.2

2025-12-17

PREAI

Elgohary, Mohamed K.; Elkotamy, Mahmoud S.; Elsayed, Zainab M.; Abdelraheem, Abrar Mortada; Radwan, Ibrahim Taha; Darweish, Eman; Almehizia, Abdulrahman A.; Naglah, Ahmed M.; Almehizia, Fahad A.; Fares, Mohamed; Eldehna, Wagdy M.; Abdel-Aziz, Hatem A.

Piperidine-based small molecules as dual-stage antileishmanial agents targeting parasite folate pathway 哌啶类小分子作为靶向寄生虫叶酸通路的双阶段抗利什曼病剂

Bioorganic Chemistry

IF4.7

2025-12-16

PREAI

Tarfah Al-Warhi; Haytham O. Tawfik; Nermeen M. Rashad; Moataz A. Shaldam; Sherry N. Nasralla; Tamer M. Ibrahim; Adnan A. Bekhit; Wagdy M. Eldehna

研究方向